Medicina clinica · 2026
Clinical characteristics and outcomes of mechanical thrombectomy in acute ischemic stroke: a cross-sectional study with subgroup analysis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Medina Rodríguez Antonio, Rodríguez Vallejo Alejandro, González López Amaranta, Sosa Cabrera Yolanda, Cristo Rodríguez-Pérez María, Dorta León H Lourdes, Hernández Cabezudo Ignacio, Jimenez Sosa Irene, Rodríguez-Baz Íñigo
Аннотация
BACKGROUND: Mechanical thrombectomy (MT) is the standard treatment for acute ischemic stroke (AIS) caused by large vessel occlusion. However, evidence remains limited in patients outside top-tier recommendation criteria, particularly in medium-vessel occlusions, tandem occlusions, and posterior circulation strokes.
METHODS: We conducted a retrospective, cross-sectional study of consecutive patients with AIS treated with MT at a tertiary hospital between 2012 and 2022. Clinical, radiological, and procedural data were collected. Patients were stratified according to class of recommendation, vascular territory, and occlusion segment. A favorable functional outcome was defined as a modified Rankin Scale score of 0-2 at 90 days.
RESULTS: A total of 334 patients were included (mean age 67.7±13.8 years; 52.7% women), of whom 146 (43.7%) met high-level recommendation criteria for MT. Cardioembolic etiology was the most frequent (47.6%), whereas atherosclerosis predominated in tandem occlusions. Successful recanalization was achieved in 80.3% of cases, without significant differences across subgroups. Symptomatic intracranial hemorrhage occurred in 11% of patients. Ninety-day mortality was 22.1%, reaching 34.6% in posterior circulation strokes. Overall, 58.2% of patients achieved a favorable functional outcome at 90 days, with the highest rates observed in M2 segment occlusions of the middle cerebral artery (73.5%).
CONCLUSION: MT for AIS was safe and effective across a broad range of occlusion locations, including patients outside high-level evidence criteria. These findings suggest the need for studies evaluating broader clinical profiles.
METHODS: We conducted a retrospective, cross-sectional study of consecutive patients with AIS treated with MT at a tertiary hospital between 2012 and 2022. Clinical, radiological, and procedural data were collected. Patients were stratified according to class of recommendation, vascular territory, and occlusion segment. A favorable functional outcome was defined as a modified Rankin Scale score of 0-2 at 90 days.
RESULTS: A total of 334 patients were included (mean age 67.7±13.8 years; 52.7% women), of whom 146 (43.7%) met high-level recommendation criteria for MT. Cardioembolic etiology was the most frequent (47.6%), whereas atherosclerosis predominated in tandem occlusions. Successful recanalization was achieved in 80.3% of cases, without significant differences across subgroups. Symptomatic intracranial hemorrhage occurred in 11% of patients. Ninety-day mortality was 22.1%, reaching 34.6% in posterior circulation strokes. Overall, 58.2% of patients achieved a favorable functional outcome at 90 days, with the highest rates observed in M2 segment occlusions of the middle cerebral artery (73.5%).
CONCLUSION: MT for AIS was safe and effective across a broad range of occlusion locations, including patients outside high-level evidence criteria. These findings suggest the need for studies evaluating broader clinical profiles.