Pediatrics and neonatology · 2026
Validation of the postnatal growth and retinopathy of prematurity criteria in Taiwanese: A prospective cohort study.
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Pao Shu-I, Tsai Yu-Chien, Chang Yu-Min, Chien Ke-Hung, Chen Jiann-Torng
Аннотация
BACKGROUND: While the Postnatal Growth and Retinopathy of Prematurity (G-ROP) screening criteria have undergone retrospective validation across various populations, prospective validation is essential before these criteria can be recommended for clinical use and wider adoption. We conducted a prospective study to validate the generalizability of G-ROP screening criteria in a new cohort of Taiwanese preterm newborns.
METHODS: This prospective study included 114 premature infants who were admitted to the neonatal intensive care unit between December 2019 and August 2024. The diagnostic performance of the G-ROP criteria for ROP detection were assessed.
RESULTS: Using the G-ROP criteria, 89 of 89 (specificity 100%) infants without ROP were accurately excluded, while a sensitivity of 88.0%, a positive predictive value (PPV) of 100.0% and a negative predictive value (NPV) of 96.7% for any ROP were identified. This criterion exhibited a sensitivity of 87.5%, a specificity of 100.0%, a PPV of 100.0% and a NPV of 100.0% for identifying type 1 ROP; a sensitivity of 100.0%, a specificity of 100.0%, a PPV of 100% and a NPV of 98.9% for identifying type 2 ROP; and a sensitivity of 0%, a specificity of 100.0%, a PPV of 0% and a NPV of 97.8% for identifying A-ROP. Compared to the screening criteria of currently recommended body weight and gestational age, G-ROP criteria reduced unnecessary examinations in 26 infants (23%) without any ROP.
CONCLUSIONS: This prospective study demonstrated that G-ROP criteria are generalizable and may reduce lower-risk infants (who did not develop treatment-requiring ROP during follow-up) receiving examination, exhibiting higher sensitivity, specificity, PPV and NPV for ROP detection than currently recommended guideline.
METHODS: This prospective study included 114 premature infants who were admitted to the neonatal intensive care unit between December 2019 and August 2024. The diagnostic performance of the G-ROP criteria for ROP detection were assessed.
RESULTS: Using the G-ROP criteria, 89 of 89 (specificity 100%) infants without ROP were accurately excluded, while a sensitivity of 88.0%, a positive predictive value (PPV) of 100.0% and a negative predictive value (NPV) of 96.7% for any ROP were identified. This criterion exhibited a sensitivity of 87.5%, a specificity of 100.0%, a PPV of 100.0% and a NPV of 100.0% for identifying type 1 ROP; a sensitivity of 100.0%, a specificity of 100.0%, a PPV of 100% and a NPV of 98.9% for identifying type 2 ROP; and a sensitivity of 0%, a specificity of 100.0%, a PPV of 0% and a NPV of 97.8% for identifying A-ROP. Compared to the screening criteria of currently recommended body weight and gestational age, G-ROP criteria reduced unnecessary examinations in 26 infants (23%) without any ROP.
CONCLUSIONS: This prospective study demonstrated that G-ROP criteria are generalizable and may reduce lower-risk infants (who did not develop treatment-requiring ROP during follow-up) receiving examination, exhibiting higher sensitivity, specificity, PPV and NPV for ROP detection than currently recommended guideline.