Annals of the Academy of Medicine, Singapore · 2003
Clinical profile and treatment outcome of livedoid vasculitis: a case series.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lee S S, Ang P, Tan S H
Аннотация
INTRODUCTION: Livedoid vasculitis is a painful ulcerative condition affecting the legs that is often difficult to treat. In this case series, the clinical profile of 6 patients with livedoid vasculitis and their treatment response to aspirin and pentoxifylline are reported.
MATERIALS AND METHODS: This is an open trial. Investigations to exclude secondary causes of livedoid vasculitis were done. Skin biopsies were performed for histology and direct immunofluorescence. Four patients were treated with pentoxifylline and 2 with aspirin. Response to treatment was assessed at the third and sixth weeks. Thereafter, treatment was individualised according to each patient's clinical response.
RESULTS: Only 1 out of 6 patients had a good response. This patient was treated with pentoxifylline. Most patients required treatment with drugs such as prednisolone, colchicine and azathioprine to control disease activity after the trial period.
CONCLUSION: Pentoxifylline or aspirin did not result in significant improvement for most of our patients when used alone. Combination with immunosuppressive treatment yielded better results.
MATERIALS AND METHODS: This is an open trial. Investigations to exclude secondary causes of livedoid vasculitis were done. Skin biopsies were performed for histology and direct immunofluorescence. Four patients were treated with pentoxifylline and 2 with aspirin. Response to treatment was assessed at the third and sixth weeks. Thereafter, treatment was individualised according to each patient's clinical response.
RESULTS: Only 1 out of 6 patients had a good response. This patient was treated with pentoxifylline. Most patients required treatment with drugs such as prednisolone, colchicine and azathioprine to control disease activity after the trial period.
CONCLUSION: Pentoxifylline or aspirin did not result in significant improvement for most of our patients when used alone. Combination with immunosuppressive treatment yielded better results.