Archivos de cardiologia de Mexico · 2026
Real-world outcomes of tafamidis in transthyretin amyloid cardiomyopathy.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Valcuende-Rosique Javier M, Revilla-Martí Pablo, Valcuende-Rosique Alejandro M, Méndez-Portuburu David, Puglla-Sánchez Luis R, Ruiz-Arroyo José R
Аннотация
BACKGROUND: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive infiltrative cardiomyopathy associated with substantial morbidity and mortality. Although tafamidis has shown clinical benefit in randomized trials, real-world data are needed to contextualize outcomes in routine practice.
OBJECTIVE: To describe baseline characteristics, extracardiac diagnostic red flags, and longitudinal outcomes in patients with ATTR-CM treated with tafamidis.
METHOD: This retrospective, longitudinal, single-center study included consecutive patients with ATTR-CM who started tafamidis between July 2019 and April 2025. The primary endpoint was 24-month overall survival estimated with Kaplan-Meier methods. Secondary endpoints included heart failure hospitalization and changes in New York Heart Association (NYHA) functional class.
RESULTS: Thirty-eight patients were included; the mean age was 82.1 ± 5.3 years, 92.1% were men, and 97.4% had wild-type disease. At baseline, 94.7% were in NYHA Class I-II, and 92.1% were in Gillmore Stage I-II. Extracardiac diagnostic red flags were frequent, particularly carpal tunnel syndrome (52.6%), which preceded cardiac diagnosis by a median of 7.0 years. During a median follow-up of 18.0 months, 3 patients (7.9%) died; estimated overall survival was 94.1% at 12 and 24 months. Only 2 patients (5.3%) had heart failure hospitalization, and 75.0% remained clinically stable or improved.
CONCLUSION: In routine clinical practice, patients treated with tafamidis, mostly at an early disease stage, showed high short- and mid-term survival, low heart failure hospitalization, and predominant clinical stabilization. Extracardiac diagnostic red flags frequently preceded cardiac diagnosis, supporting earlier recognition.
OBJECTIVE: To describe baseline characteristics, extracardiac diagnostic red flags, and longitudinal outcomes in patients with ATTR-CM treated with tafamidis.
METHOD: This retrospective, longitudinal, single-center study included consecutive patients with ATTR-CM who started tafamidis between July 2019 and April 2025. The primary endpoint was 24-month overall survival estimated with Kaplan-Meier methods. Secondary endpoints included heart failure hospitalization and changes in New York Heart Association (NYHA) functional class.
RESULTS: Thirty-eight patients were included; the mean age was 82.1 ± 5.3 years, 92.1% were men, and 97.4% had wild-type disease. At baseline, 94.7% were in NYHA Class I-II, and 92.1% were in Gillmore Stage I-II. Extracardiac diagnostic red flags were frequent, particularly carpal tunnel syndrome (52.6%), which preceded cardiac diagnosis by a median of 7.0 years. During a median follow-up of 18.0 months, 3 patients (7.9%) died; estimated overall survival was 94.1% at 12 and 24 months. Only 2 patients (5.3%) had heart failure hospitalization, and 75.0% remained clinically stable or improved.
CONCLUSION: In routine clinical practice, patients treated with tafamidis, mostly at an early disease stage, showed high short- and mid-term survival, low heart failure hospitalization, and predominant clinical stabilization. Extracardiac diagnostic red flags frequently preceded cardiac diagnosis, supporting earlier recognition.