Efficacy of a modified digital unified protocol targeting both positive and negative emotion regulation: A randomized clinical trial.

OBJECTIVE

The Unified Protocol (UP) has proven effective for treating emotional disorders; however, its standard format primarily focuses on regulating negative emotions. While difficulties with negative emotion regulation are common across these disorders, difficulties with positive emotion regulation are often overlooked. This study evaluated the efficacy of a digitally adapted UP incorporating positive emotion regulation strategies (internet-delivered unified protocol+).

METHOD: In a randomized clinical trial, 120 adults (Mage = 34.0, SD = 12.0; 73% female; 75% White) with principal anxiety, depressive, or obsessive-compulsive disorders were assigned to the internet-delivered unified protocol+ (n = 80) or standard internet-delivered unified protocol (n = 40). Both 12-week programs occurred via an online platform with asynchronous clinical support through weekly messaging. Outcomes included anxiety, depression, and stress; positive/negative affect; functional impairment; savoring; positive mental health; and flourishing. Analyses included between- and within-group effect sizes, remission comparisons, and latent growth modeling.

RESULTS

Both groups demonstrated statistically significant reductions in anxiety, depression, stress, negative affect, and functional impairment (standardized mean gain effect size ≈ -0.28 to -1.13) that were maintained across a 3-month follow-up. Statistically significant, small-to-moderate gains in positive mental health and flourishing (standardized mean gain effect size ≈ 0.31-0.37) were also observed and maintained. Positive affect and savoring significantly increased by Week 8 but diminished and were no longer significant at follow-up. No group differences emerged for any outcome.

CONCLUSIONS

Digital UP interventions were associated with symptom reduction and improvements in flourishing, but adding positive emotion regulation content did not yield incremental benefits. Future research should explore whether increased intensity or duration of these strategies improves outcomes. (PsycInfo Database Record (c) 2026 APA, all rights reserved).