Neuroradiology · 2025
Similar DTI-ALPS metrics in Parkinson's disease and essential tremor: a cross-sectional comparative analysis.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Bruno Federico, Innocenzi Antonio, Badini Pierfrancesco, Cella Marco, Santobuono Chiara, Pertici Leonardo, Catalucci Alessia, Saporito Gennaro, Sucapane Patrizia, Palumbo Pierpaolo, Arrigoni Francesco, Barile Antonio, Di Cesare Ernesto, Pistoia Francesca, Splendiani Alessandra
Аннотация
PURPOSE: This study investigated glymphatic function in tremor disorders using the diffusion tensor imaging-derived ALPS (analysis-along-the-perivascular-space) index, a non-invasive surrogate of perivascular fluid movement.
MATERIALS AND METHODS: Fourty-three patients with tremor-dominant Parkinson's disease (PD, n=22) or essential tremor (ET, n=21), aged 50-75, were retrospectively compared with 18 age-matched healthy controls (HC) imaged with the same 3 T MRI protocol. Subjects with significant cognitive impairment, white matter disease, other CNS disorders, or poor-quality diffusion data were excluded. ALPS indices were calculated from projection and association fibre regions.
RESULTS: Both PD (mean ALPS = 1.34 ± 0.19) and ET ( 1.31 ± 0.13) groups exhibited 12 significantly lower ALPS values than HC ( 1.54±0.11 P < 0.05), but no difference was 13 found between PD and ET. In PD, lower ALPS correlated with greater tremor severity and older age, particularly in the right hemisphere (R²=0.80, p=0.003). ET showed weaker clinical associations though MoCA correlated positively with right-hemisphere ALPS (ρ=0.462, p=0.018). CONCLUSION: The findings indicate perivascular diffusivity is reduced in both tremor-dominant PD and ET, supporting a role for glymphatic dysfunction in their pathophysiology, though larger, prospective studies are needed to validate this observation.
MATERIALS AND METHODS: Fourty-three patients with tremor-dominant Parkinson's disease (PD, n=22) or essential tremor (ET, n=21), aged 50-75, were retrospectively compared with 18 age-matched healthy controls (HC) imaged with the same 3 T MRI protocol. Subjects with significant cognitive impairment, white matter disease, other CNS disorders, or poor-quality diffusion data were excluded. ALPS indices were calculated from projection and association fibre regions.
RESULTS: Both PD (mean ALPS = 1.34 ± 0.19) and ET ( 1.31 ± 0.13) groups exhibited 12 significantly lower ALPS values than HC ( 1.54±0.11 P < 0.05), but no difference was 13 found between PD and ET. In PD, lower ALPS correlated with greater tremor severity and older age, particularly in the right hemisphere (R²=0.80, p=0.003). ET showed weaker clinical associations though MoCA correlated positively with right-hemisphere ALPS (ρ=0.462, p=0.018). CONCLUSION: The findings indicate perivascular diffusivity is reduced in both tremor-dominant PD and ET, supporting a role for glymphatic dysfunction in their pathophysiology, though larger, prospective studies are needed to validate this observation.