Frontiers in cellular and infection microbiology · 2026
Older adults with constipation and Parkinson's disease share comparable gut microbiota.
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Ke Leyong, Wang Yue, Tang Li, Yang Min, Liu Qinxin, Wu Jianfei, Bi Xiaogang, Chen Yunbo, Liu Xin
Аннотация
BACKGROUND: Aging underlies numerous diseases, including Parkinson's disease (PD) and constipation. A large proportion of patients with PD often suffer from constipation; however, it remains unclear whether older patients with constipation and those with Parkinson's disease share common gut microbiota characteristics.
AIM: This study analyzed the characteristics of the gut microbiota in older adults with constipation or PD to identify differences and similarities and to evaluate the possible role of the microbiota in PD and constipation.
METHODS: Raw data from fecal samples of 860 selected older adults from the Gut Microbiota Database (GMrepo) were analyzed, including patients with PD (n=378), constipation (CP, n=189), and healthy participants (CON, n=293).
RESULTS: The CP group displayed a higher relative abundance of Bacteroides and Akkermansia, and a decreased relative abundance of Prevotella, Faecalibacterium, and Agathobacterium than the CON group. Similarly, the PD group exhibited an increased relative abundance of Bacteroides, Akkermansia, Parabacteroides, Phascolarctobacterium, and Bifidobacterium, and a decreased relative abundance of Escherichia-Shigella, Faecalibacterium, Agathobacterium, and Prevotella. Further analysis revealed that, compared with the CON group, most bacteria were enriched or deficient in the CP and PD groups, such as Bacteroides, Akkermansia, Faecalibacterium, Agathobacterium, and Prevotella.
CONCLUSION: The microbiota composition and structure of older adults with constipation or PD were similar and significantly different from those of healthy controls. This may partially explain the coexistence of constipation and PD in terms of the gut microbiota.
AIM: This study analyzed the characteristics of the gut microbiota in older adults with constipation or PD to identify differences and similarities and to evaluate the possible role of the microbiota in PD and constipation.
METHODS: Raw data from fecal samples of 860 selected older adults from the Gut Microbiota Database (GMrepo) were analyzed, including patients with PD (n=378), constipation (CP, n=189), and healthy participants (CON, n=293).
RESULTS: The CP group displayed a higher relative abundance of Bacteroides and Akkermansia, and a decreased relative abundance of Prevotella, Faecalibacterium, and Agathobacterium than the CON group. Similarly, the PD group exhibited an increased relative abundance of Bacteroides, Akkermansia, Parabacteroides, Phascolarctobacterium, and Bifidobacterium, and a decreased relative abundance of Escherichia-Shigella, Faecalibacterium, Agathobacterium, and Prevotella. Further analysis revealed that, compared with the CON group, most bacteria were enriched or deficient in the CP and PD groups, such as Bacteroides, Akkermansia, Faecalibacterium, Agathobacterium, and Prevotella.
CONCLUSION: The microbiota composition and structure of older adults with constipation or PD were similar and significantly different from those of healthy controls. This may partially explain the coexistence of constipation and PD in terms of the gut microbiota.