Indian journal of ophthalmology · 2026
Role of Insulin-like growth factor-1 and postnatal growth failure in retinopathy of prematurity development in babies weighing less than 1500 grams at birth - A prospective cohort study.
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Abburu Charita, Deb Amit Kumar, Plakkal Nishad, Nandeesha Hanumanthappa, Temkar Shreyas
Аннотация
PURPOSE: Low postnatal serum insulin-like growth factor-1 (IGF-1) levels and slow postnatal weight gain are associated with severe retinopathy of prematurity (ROP) in many Western studies. However, similar studies in the Indian cohort are limited. The objective of this study is to determine the role of IGF-1 and postnatal growth failure (PNGF) in predicting ROP in an Indian cohort.
DESIGN: Prospective observational cohort study.
METHODS: This was a prospective observational study. Babies screened for ROP were categorized based on the highest ROP stage in either eye. Weekly birth weight was estimated and growth failure was diagnosed based on Z score. Blood samples for IGF-1 estimation were collected between 30 and 33 weeks.
RESULTS: The median IGF-1 levels were lower in the babies with any stage ROP (18.82 ng/ml) than in no ROP (28.81 ng/ml) ( P = 0.002). On logistic regression analysis, PNGF was independently associated with ROP development with an odds ratio of 2.07 (CI 1.04-4.11). The area under the curve of receiver operating characteristic for both IGF-1 levels and postnatal weight gain was > 0.5, implying good diagnostic accuracy in predicting ROP.
CONCLUSION: Poor weight gain rate, PNGF, and low IGF-1 are important predictors for ROP and help to identify the neonates with poor postnatal development. Such babies should therefore be followed meticulously during ROP screening.
DESIGN: Prospective observational cohort study.
METHODS: This was a prospective observational study. Babies screened for ROP were categorized based on the highest ROP stage in either eye. Weekly birth weight was estimated and growth failure was diagnosed based on Z score. Blood samples for IGF-1 estimation were collected between 30 and 33 weeks.
RESULTS: The median IGF-1 levels were lower in the babies with any stage ROP (18.82 ng/ml) than in no ROP (28.81 ng/ml) ( P = 0.002). On logistic regression analysis, PNGF was independently associated with ROP development with an odds ratio of 2.07 (CI 1.04-4.11). The area under the curve of receiver operating characteristic for both IGF-1 levels and postnatal weight gain was > 0.5, implying good diagnostic accuracy in predicting ROP.
CONCLUSION: Poor weight gain rate, PNGF, and low IGF-1 are important predictors for ROP and help to identify the neonates with poor postnatal development. Such babies should therefore be followed meticulously during ROP screening.