Generation of an induced pluripotent stem cell line (NIMHi032-A) from a progressive supranuclear Palsy-Richardson's syndrome patient of Indian ethnicity.

Progressive Supranuclear Palsy (PSP) is a rare atypical Parkinsonian disorder associated with tau pathology, with an estimated global incidence of 1-18 cases per 100,000 individuals per year. Richardson Syndrome (PSP-RS) is the most prevalent clinical subtype. Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells of a clinically confirmed PSP-RS patient using Sendai virus-mediated reprogramming. Comprehensive characterization confirmed their self-renewal ability and the expression of markers associated with the undifferentiated pluripotent state. The resulting iPSC line serves as a valuable biological resource for investigating disease pathophysiology in derived cell types and provides a valuable platform for biomarker discovery and drug screening.