Methodology of a Large Multicenter Observational Study of Patients with COVID-19 in Spanish Intensive Care Units.
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Torres Antoni, Motos Anna, Ceccato Adrián, Bermejo-Martin Jesús, de Gonzalo-Calvo David, Pérez Raquel, Barroso Marta, Pascual Ion Zubizarreta, Gonzalez Jessica, Fernández-Barat Laia, Ferrer Ricard, Riera Jordi, García-Gasulla Dario, Peñuelas Oscar, Lorente José Ángel, Almansa Raquel, Menéndez Rosario, Kiarostami Kasra, Canseco Joan, Villar Rosario Amaya, Añón José M, Mariño Ana Balan, Barberà Carme, Barberán José, Ortiz Aaron Blandino, Boado Maria Victoria, Bustamante-Munguira Elena, Caballero Jesús, Cantón-Bulnes María Luisa, Pérez Cristina Carbajales, Carbonell Nieves, Catalán-González Mercedes, de Frutos Raúl, Franco Nieves, Galbán Cristóbal, Gumucio-Sanguino Víctor D, Torre María Del Carmen de la, Díaz Emili, Estella Ángel, Gallego Elena, Garmendia José Luis García, Gómez José M, Huerta Arturo, García Ruth Noemí Jorge, Loza-Vázquez Ana, Marin-Corral Judith, Delgado María Cruz Martin, Gándara Amalia Martínez de la, Varela Ignacio Martínez, Messa Juan López, Albaiceta Guillermo M, Nieto Maite, Novo Mariana Andrea, Peñasco Yhivian, Pérez-García Felipe, Pozo-Laderas Juan Carlos, Ricart Pilar, Sagredo Víctor, Sánchez-Miralles Ángel, Chinesta Susana Sancho, Serra-Fortuny Mireia, Socias Lorenzo, Solé-Violan Jordi, Suárez-Sipmann Fernando, Lomas Luis Tamayo, Trenado José, Úbeda Alejandro, Valdivia Luis Jorge, Vidal Pablo, Barbé Ferran, CIBERESUCICOVID Project (COV20/00110, ISCIII)
Аннотация
METHODS: CIBERESUCICOVID is a multicenter, observational, prospective/retrospective cohort study of patients with COVID-19 admitted to Spanish ICUs. Several work packages were created, including study population and ICU data collection, follow-up, biomarkers and miRNAs, data management and quality.
RESULTS: This study included 6102 consecutive patients admitted to 55 ICUs homogeneously distributed throughout Spain and the collection of blood samples from more than 1000 patients. We enrolled a large population of COVID-19 ICU-admitted patients including baseline characteristics, ICU and MV data, treatments complications, and outcomes. The in-hospital mortality was 31%, and 76% of patients required invasive mechanical ventilation. A 3-6 month and 1 year follow-up was performed. Few deaths after 1 year discharge were registered. Low anti-SARS-CoV-2 S antibody levels predict mortality in critical COVID-19. These antibodies contribute to prevent systemic dissemination of SARS-CoV-2. The severity of COVID-19 impacts the circulating miRNA profile. Plasma miRNA profiling emerges as a useful tool for risk-based patient stratification in critically ill COVID-19 patients.
CONCLUSIONS: We present the methodology used in a large multicenter study sponsored by ISCIII to determine the short- and long-term outcomes in patients with COVID-19 admitted to more than 50 Spanish ICUs.