Annals of nuclear medicine · 2026
Semi-quantitative evaluation of early phase 99mTc-DPD scintigraphy in patients with suspected cardiac amyloidosis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kessler Lukas, Ferber Leon, Rischpler Christoph, Settelmeier Stephan, Telli Tugce, Varasteh Zohreh, Spielvogel Clemens P, Hagenacker Tim, Fendler Wolfgang P, Carpinteiro Alexander, Michel Lars, Herrmann Ken, Rassaf Tienush, Sraieb Miriam, Kersting David
Аннотация
BACKGROUND: Scintigraphy using bone-avid tracers like 99mTc-diphosphono-propanodicarboxylic acid (99mTc-DPD), 99mTc-hydroxymethylene-diphosphonate (99mTc-HMDP), or 99mTc-pyrophosphate (99mTc-PYP) is a widely available and non-invasive imaging tool for diagnosis of cardiac amyloidosis. Visual evaluation and semi-quantitative image analyses reach excellent sensitivity and specificity results. For 99mTc-HMDP, high accuracy of early semi-quantitative parameters derived from imaging 10 min after tracer injection was described but never validated for other tracers. The aim of this study was to evaluate early semi-quantitative parameters in 99mTc-DPD scintigraphy.
METHODS: 122 patients (78 male / 44 female) with suspected cardiac amyloidosis who underwent 99mTc-DPD scintigraphy were retrospectively analysed. Early and late planar whole-body scintigraphy images were acquired 10 min (+ 5 min) and 2.5–3.5 h after tracer injection. Early cardiac 99mTc-DPD uptake was evaluated using the Heart/whole-body rectangular (H/WBr), Heart/whole-body profile (H/WBp), Heart/Skull (H/S), Heart/Mediastinum (H/M), Heart/Contralateral Lung (H/CL), Heart/Liver (H/L), and Heart/Pelvis (H/P) ratios.
RESULTS: H/L was not correlated to the other parameters.Best results for prediction of Perugini ≥1 were achieved for H/M (sensitivity 69.6%, specificity 84.4%, accuracy 77.5%), best results for prediction of ATTR-CA for H/L (sensitivity 65.9%, specificity 88.6%, accuracy 80.8%). Adding the H/L to other parameters increased accuracy and specificity (best results for H/L+H/S: accuracy 83.3%, sensitivity 63.4%, specificity 93.7% to predict CA).
CONCLUSION: Previous results for99mTc-HMDP were not confirmed; diagnostic precision of early 99mTc-DPD is not sufficient to replace late imaging in clinical routine. Early H/L is a novel, independent, and specific parameter which may be added to imaging protocols to increase the accuracy in combination with other imaging biomarkers
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12149-026-02209-w.
METHODS: 122 patients (78 male / 44 female) with suspected cardiac amyloidosis who underwent 99mTc-DPD scintigraphy were retrospectively analysed. Early and late planar whole-body scintigraphy images were acquired 10 min (+ 5 min) and 2.5–3.5 h after tracer injection. Early cardiac 99mTc-DPD uptake was evaluated using the Heart/whole-body rectangular (H/WBr), Heart/whole-body profile (H/WBp), Heart/Skull (H/S), Heart/Mediastinum (H/M), Heart/Contralateral Lung (H/CL), Heart/Liver (H/L), and Heart/Pelvis (H/P) ratios.
RESULTS: H/L was not correlated to the other parameters.Best results for prediction of Perugini ≥1 were achieved for H/M (sensitivity 69.6%, specificity 84.4%, accuracy 77.5%), best results for prediction of ATTR-CA for H/L (sensitivity 65.9%, specificity 88.6%, accuracy 80.8%). Adding the H/L to other parameters increased accuracy and specificity (best results for H/L+H/S: accuracy 83.3%, sensitivity 63.4%, specificity 93.7% to predict CA).
CONCLUSION: Previous results for99mTc-HMDP were not confirmed; diagnostic precision of early 99mTc-DPD is not sufficient to replace late imaging in clinical routine. Early H/L is a novel, independent, and specific parameter which may be added to imaging protocols to increase the accuracy in combination with other imaging biomarkers
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12149-026-02209-w.