Ophthalmology science · 2026
Assessing Polypoidal Choroidal Vasculopathy-Related OCT Features in the TENAYA and LUCERNE Trials.
СтатьяНазвание и аннотация: Перевод в очереди
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Teo Kelvin Yi Chong, Margaron Philippe, Lai Timothy Y Y, Lee Won Ki, Sadda Srinivas R, Staurenghi Giovanni, Patel Shriji, Cheung Chui Ming Gemmy
Аннотация
OBJECTIVE: To describe OCT features associated with polypoidal choroidal vasculopathy (PCV) in the TENAYA and LUCERNE clinical trial cohorts.
DESIGN: Imaging analysis within 2 multinational, double-masked, randomized controlled phase III trials.
SUBJECTS: Participants with treatment-naïve neovascular age-related macular degeneration enrolled in TENAYA and LUCERNE with baseline OCT and in a subset, baseline indocyanine green angiography (ICGA).
METHODS: Previously described OCT features associated with PCV were evaluated among 1329 participants. Two major OCT features were evaluated (sharp-peaked pigment epithelial detachment [SPED] and sub-retinal pigment epithelium ring-like lesion) to determine the occurrence of OCT-defined PCV. Subretinal fluid, intraretinal fluid (IRF), and hyperreflective material (HRM), were compared between OCT-defined PCV and non-PCV eyes. A sensitivity analysis was performed in the subset of eyes with available ICGA to assess concordance between OCT and ICGA-confirmed PCV.
MAIN OUTCOME MEASURES: Occurrence of OCT-defined PCV and distribution of OCT-based disease activity biomarkers by PCV status.
RESULTS: Using the 2 major OCT criteria, 88 (6.7%) of eyes were classified as OCT-defined PCV. Fewer OCT-defined PCV eyes had IRF and HRM compared with non-PCV eyes (27.3% vs. 45.5%, P = 0.002, 19.3% vs. 47.0%, P < 0.001). In the ICGA subset (n = 274), the combination of SPED and ring demonstrated good sensitivity (85.2%) and high specificity (98.8%) relative to ICGA.
CONCLUSIONS: Using 2 Asia-Pacific Ocular Imaging Society major OCT features, OCT-based diagnostic strategy may help triage or screen for PCV when ICGA is unavailable.
FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
DESIGN: Imaging analysis within 2 multinational, double-masked, randomized controlled phase III trials.
SUBJECTS: Participants with treatment-naïve neovascular age-related macular degeneration enrolled in TENAYA and LUCERNE with baseline OCT and in a subset, baseline indocyanine green angiography (ICGA).
METHODS: Previously described OCT features associated with PCV were evaluated among 1329 participants. Two major OCT features were evaluated (sharp-peaked pigment epithelial detachment [SPED] and sub-retinal pigment epithelium ring-like lesion) to determine the occurrence of OCT-defined PCV. Subretinal fluid, intraretinal fluid (IRF), and hyperreflective material (HRM), were compared between OCT-defined PCV and non-PCV eyes. A sensitivity analysis was performed in the subset of eyes with available ICGA to assess concordance between OCT and ICGA-confirmed PCV.
MAIN OUTCOME MEASURES: Occurrence of OCT-defined PCV and distribution of OCT-based disease activity biomarkers by PCV status.
RESULTS: Using the 2 major OCT criteria, 88 (6.7%) of eyes were classified as OCT-defined PCV. Fewer OCT-defined PCV eyes had IRF and HRM compared with non-PCV eyes (27.3% vs. 45.5%, P = 0.002, 19.3% vs. 47.0%, P < 0.001). In the ICGA subset (n = 274), the combination of SPED and ring demonstrated good sensitivity (85.2%) and high specificity (98.8%) relative to ICGA.
CONCLUSIONS: Using 2 Asia-Pacific Ocular Imaging Society major OCT features, OCT-based diagnostic strategy may help triage or screen for PCV when ICGA is unavailable.
FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.