Parkinsonism & related disorders · 2025
Age-matched comparison of focused ultrasound thalamotomy for tremor in Parkinson's disease and essential tremor: A two-center retrospective study.
СтатьяМногоцентровое исследованиеСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Gaudiano Gianfranco, Cheyuo Cletus, Braccia Arianna, Golfrè Andreasi Nico, Levi Vincenzo, Lozano Andres M, Fasano Alfonso, Cilia Roberto, Eleopra Roberto
Аннотация
INTRODUCTION: Magnetic resonance-guided Focused ultrasound (MRgFUS) thalamotomy for tremors has been suggested to be more effective in essential tremor (ET) compared to Parkinson's disease (PD). Age has been proposed as a potential predictor of response, with opposite trends between PD and ET, and may contribute to the observed differences in outcomes. This study aims to compare the outcome of unilateral MRgFUS-thalamotomy in age-matched cohorts of PD and ET patients.
METHODS: Consecutive ET and PD patients treated with MRgFUS-thalamotomy in the two centers were enrolled and matched by age. Tremor severity was evaluated at baseline and at 6 and 12 months post-treatment using disease-specific scales for ET and PD.
RESULTS: Sixty-four patients (40 ET, 24 PD) were evaluated at 6 months (22 ET and 8 PD reached the 12 months follow-up). ET and PD patients showed a comparable tremor improvement at 6-month follow-up. The benefit observed persisted at 12-months CONCLUSION: Head-to-head outcome comparison of unilateral MRgFUS-thalamotomy did not reveal major differences between ET and PD matched by age.
METHODS: Consecutive ET and PD patients treated with MRgFUS-thalamotomy in the two centers were enrolled and matched by age. Tremor severity was evaluated at baseline and at 6 and 12 months post-treatment using disease-specific scales for ET and PD.
RESULTS: Sixty-four patients (40 ET, 24 PD) were evaluated at 6 months (22 ET and 8 PD reached the 12 months follow-up). ET and PD patients showed a comparable tremor improvement at 6-month follow-up. The benefit observed persisted at 12-months CONCLUSION: Head-to-head outcome comparison of unilateral MRgFUS-thalamotomy did not reveal major differences between ET and PD matched by age.