Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2016
RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1,6-nonadien-3-ol, CAS Registry Number 10339-55-6.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Api A M, Belsito D, Bhatia S, Bruze M, Calow P, Dagli M L, Dekant W, Fryer A D, Kromidas L, La Cava S, Lalko J F, Lapczynski A, Liebler D C, Miyachi Y, Politano V T, Ritacco G, Salvito D, Schultz T W, Shen J, Sipes I G, Wall B, Wilcox D K
Аннотация
The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog linalool (CAS # 78-70-6) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the local respiratory endpoint. The repeated dose, developmental and reproductive toxicity endpoints were completed using nerolidol (isomer unspecified, CAS # 7212-44-4) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.