Anti-apoptotic Role of Bcl-2-Associated Athanogene-3 Protein Overexpression in the Pathogenesis of Endometrial Cancers: An Aid for New Therapeutic Targets.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Pradhan A, Müser M H, Miller N, Abdelnabe J P, Afferrante L, Albertini D, Aldave D A, Algieri L, Ali N, Almqvist A, Amann T, Ares P, Balzer B N, Baugh L, Berberich E A, Björling M, Bobji M S, Bottiglione F, Brodmann B, Cai W, Carbone G, Carpick R W, Cassin F, Cayer-Barrioz J, Chowdhury M I, Ciavarella M, Cihan E, Huang D, Delplanque E, Deptula A J, Descartes S, Dhinojwala A, Dienwiebel M, Dini D, Dunn A C, Edwards C, Eriten M, Esawi A, Espinosa-Marzal R M, Fang L, Fatemi A, Fidd C, Gabriel D, Gaslain F, Giordano G, Gómez-Herrero J, Gontard L, Gosvami N N, Greenwood G, Greiner C, Grejtak T, Haroun A, Hasan M, Hoppe S, Isa L, Jackson R L, Jang S, Johnson O, Kaiser F, Kalin M, Kalliorinne K, Karanjkar P H, Kim S H, Kinzelberger S, Klapetek P, Krick B A, Kumar C, Kumar N, Kumar S, LaMascus P, Larsson R, Laux P, Lee M J, Lee P M, Lee W, Leriche C, Li J, Li Y, Li Y-S, Lubrecht T A, Lyashenko I A, Ma C, Ma T, Maaboudallah F, Mahmood S, Mangolini F, Marian M, Mazuyer D, Meng Y, Menga N, Miller T, Mulvihill D M, Najah M, Nečas D, Papadopoulos C I, Papangelo A, Pauli M, Persson B N J, Peterson A, Pitenis A A, Podsiadlo P, Polajnar M, Popov V L, Požar T, Prasad A, Prieto G, Putignano C, Rahman M H, Ramisetti S B, Raumel S, Reyes I J, Rodriguez N, Rodríguez Ripoll M, Rojacz H, Sainsot P, Samodurova A, Savio D, Scaraggi M, Schaefer F, Scherrer S W, Schulze K D, Shaffer K E, Sidebottom M A, Skaltsas D, Soni J, Spies C, Stachowiak G W, Steinhoff L, Strandwitz N C, Sun K, Tripathi S, Tuckart W R, Ugar S, Valtr M, Van Meter K E, Vdovak J, Vilhena J G, Violano G, Vorlaufer G, Walczak M, Weber B, Woloszynski T, Wolski M, Yadav A, Yastrebov V A, Yongjian M, Yuan L, Yus J, Zhang J, Zhang X, Zheng Q, Pastewka L, Jacobs T D B
Аннотация
METHODS: This was a cross-sectional study, undertaken as part of a second phase of the MASHAD cohort study, conducted between January 2025 and March 2025. Anthropometric measurements, including body mass index (BMI), weight, and height, were recorded using standardized protocols. Indirect calorimetry (IC) was used to measure basal metabolic rate (BMR) under controlled conditions. Cardiovascular events were self-reported and verified by trained personnel.
RESULTS: A subset of 964 individuals was selected from the original cohort. CVD event: CHD and stroke prevalence were 27.8% and 1.3%, respectively. Our study showed significant differences in protein oxidation, RMR/BSA, BMR, and V.O2 in CHD compared to those without CHD events (p-value < 0.05). A significant difference in BMR, V.O2, V.CO2, and protein oxidation were observed among participants with sinus bradycardia and Right bundle branch block compared to those without CVD (P-value < 0.05). In a crude model, RMR/BSA was associated with increased CHD risk (p-value = 0.028), After adjusting for potential confounders, none of the associations remained statistically significant (p-value > 0.05).
CONCLUSION: This study identified significant differences in specific indirect calorimetry parameters between groups; however, after adjusting for potential confounders, none of the associations remained statistically significant. These findings should be interpreted with caution and require confirmation in future prospective studies. Elevated protein oxidation, V.O₂, RMR/BSA, and BMR showed associations with CHD and stroke in unadjusted analyses; these findings show potential associations that warrant further investigation.