Immunopharmacology and immunotoxicology · 2026
Effect of zinc oxide nanoparticles on circulating neutrophils in carbon tetrachloride (CCl4) induced liver fibrosis in rats.
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Youssry Sara, Abd-Elfattah Darwish Amira, A Matar Noura, Ibrahim Shalaby Thanaa
Аннотация
OBJECTIVE: The current study aimed to evaluate the modulatory effects of chemically prepared and Rhus coriaria (sumac) green-synthesized zinc oxide nanoparticles (ZnO-NPs) on circulating neutrophils and the histological structure of liver in carbon tetrachloride (CCl4) treated rats.
RESULTS: CCl4 rats showed biochemical changes and histopathological damage, together with increased neutrophil markers [myeloperoxidase (MPO) and citrullinated histone (H3cit)] as well as decreased neutrophils' phagocytic activity and miR-223 expression compared to control. ZnO-NPs treatment was significantly associated with biochemical and histopathological improvement, decreased neutrophil markers, and increased both phagocytic activity and miR-223 expression. In addition, green-synthesized ZnO-NPs were associated with greater histopathological improvement and a significant increase in miR-223 expression in comparison to chemically prepared ZnO-NPs.
CONCLUSIONS: It can be concluded that ZnO-NPs may have immunomodulatory effects on circulating neutrophils that have a biological impact on disease progression. In addition, green-synthesized ZnO-NPs may be more efficient than chemically synthesized ones at providing a greater modulatory effect on circulating neutrophils and better hepatoprotective effects.
RESULTS: CCl4 rats showed biochemical changes and histopathological damage, together with increased neutrophil markers [myeloperoxidase (MPO) and citrullinated histone (H3cit)] as well as decreased neutrophils' phagocytic activity and miR-223 expression compared to control. ZnO-NPs treatment was significantly associated with biochemical and histopathological improvement, decreased neutrophil markers, and increased both phagocytic activity and miR-223 expression. In addition, green-synthesized ZnO-NPs were associated with greater histopathological improvement and a significant increase in miR-223 expression in comparison to chemically prepared ZnO-NPs.
CONCLUSIONS: It can be concluded that ZnO-NPs may have immunomodulatory effects on circulating neutrophils that have a biological impact on disease progression. In addition, green-synthesized ZnO-NPs may be more efficient than chemically synthesized ones at providing a greater modulatory effect on circulating neutrophils and better hepatoprotective effects.