Journal of perinatology : official journal of the California Perinatal Association · 2026
Neurodevelopmental impairment in preterm infants following progressive post-hemorrhagic ventricular dilatation.
СтатьяНазвание и аннотация: Перевод в очереди
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Musiime Grace M, Hendson Leonora, Mohammad Khorshid, Kwong Grace P S, Riva-Cambrin Jay, Benlamri Amina, Tang Selphee, Scott James N, Momin Sarfaraz, Zein Hussein, Leijser Lara M
Аннотация
OBJECTIVE: To investigate the relationship of post-hemorrhagic ventricular dilatation (PHVD) with neurodevelopmental outcomes in preterm infants.
STUDY DESIGN: Retrospective cohort study of infants <29 weeks' gestation admitted from 2010-2018 with intraventricular hemorrhage and neurodevelopmental assessment at 18-21 months corrected age. Eligible infants were grouped as 'no PHVD', 'PHVD without neurosurgical intervention', and 'symptomatic PHVD with intervention'. Neurodevelopmental impairment (NDI) was assessed using generalized linear models.
RESULTS: Of 227 infants, 183 (80.6%) had no PHVD, 28 (12.3%) had PHVD without intervention, and 16 (7.0%) had PHVD with intervention. Severe NDI was observed in 14 (7.7%), 10 (35.7%), and 10 (62.5%) infants, respectively (p < 0.05). PHVD without and with intervention was associated with significantly increased risk of overall NDI (adjusted odds ratios [aOR] 6.2, 95% CI 2.4-16.5 and 18.1, 95% CI 5.5-68.4) as compared to no PHVD.
CONCLUSIONS: Progressive PHVD, irrespective of clinical symptoms, predisposes affected preterm infants to significant risk of NDI.
STUDY DESIGN: Retrospective cohort study of infants <29 weeks' gestation admitted from 2010-2018 with intraventricular hemorrhage and neurodevelopmental assessment at 18-21 months corrected age. Eligible infants were grouped as 'no PHVD', 'PHVD without neurosurgical intervention', and 'symptomatic PHVD with intervention'. Neurodevelopmental impairment (NDI) was assessed using generalized linear models.
RESULTS: Of 227 infants, 183 (80.6%) had no PHVD, 28 (12.3%) had PHVD without intervention, and 16 (7.0%) had PHVD with intervention. Severe NDI was observed in 14 (7.7%), 10 (35.7%), and 10 (62.5%) infants, respectively (p < 0.05). PHVD without and with intervention was associated with significantly increased risk of overall NDI (adjusted odds ratios [aOR] 6.2, 95% CI 2.4-16.5 and 18.1, 95% CI 5.5-68.4) as compared to no PHVD.
CONCLUSIONS: Progressive PHVD, irrespective of clinical symptoms, predisposes affected preterm infants to significant risk of NDI.