Wiadomosci lekarskie (Warsaw, Poland : 1960) · 2025
Microscopic changes in the pancreas at late stages after experimental exposure to monosodium glutamate.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kochmar Mykhailo Yu, Lytvak Yuliia V, Hetsko Oleksandr I, Kochmar Oleksandr M, Kharkhalis Ihor K, Valko Olesya O
Аннотация
OBJECTIVE: Aim: To determine the structural reorganization of the pancreas at late stages after experimental MSG exposure.
PATIENTS AND METHODS: Materials and Methods: The study was performed on 20 sexually mature male rats. The experimental group received MSG orally at 70 mg/kg of body weight daily for 8 weeks. The control group was fed a standard diet without MSG. Decapitation was performed at week 18. Pancreatic tissues were collected for histological analysis and processed by standard methods.
RESULTS: Results: Ten weeks after MSG withdrawal, atrophic areas were detected in the exocrine parenchyma. Acini and pancreatocytes decreased in size. In the ductal epithelium, dystrophic and destructive changes were observed, including cytoplasmic metachromasia, nuclear pyknosis, eccentric localization, and karyorrhexis. Periductal sclerosis and pancreatic lipomatosis were recorded. Vascular walls were thickened and homogeneous due to edema and mucoid swelling. Capillaries were plethoric with stasis and occasional perivascular hemorrhages.
CONCLUSION: Conclusions: At late stages after MSG exposure, marked alterations in pancreatic structure were revealed. Irreversible atrophic changes of exocrinocytes led to dysfunction of the gland, indicating the toxic effect of monosodium glutamate.
PATIENTS AND METHODS: Materials and Methods: The study was performed on 20 sexually mature male rats. The experimental group received MSG orally at 70 mg/kg of body weight daily for 8 weeks. The control group was fed a standard diet without MSG. Decapitation was performed at week 18. Pancreatic tissues were collected for histological analysis and processed by standard methods.
RESULTS: Results: Ten weeks after MSG withdrawal, atrophic areas were detected in the exocrine parenchyma. Acini and pancreatocytes decreased in size. In the ductal epithelium, dystrophic and destructive changes were observed, including cytoplasmic metachromasia, nuclear pyknosis, eccentric localization, and karyorrhexis. Periductal sclerosis and pancreatic lipomatosis were recorded. Vascular walls were thickened and homogeneous due to edema and mucoid swelling. Capillaries were plethoric with stasis and occasional perivascular hemorrhages.
CONCLUSION: Conclusions: At late stages after MSG exposure, marked alterations in pancreatic structure were revealed. Irreversible atrophic changes of exocrinocytes led to dysfunction of the gland, indicating the toxic effect of monosodium glutamate.