Recent outcomes of liver transplantation for Budd-Chiari syndrome: A study of the European Liver Transplant Registry (ELTR) and affiliated centers.
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Dongelmans Edo, Erler Nicole, Adam Rene, Nadalin Silvio, Karam Vincent, Yilmaz Sezai, Kelly Claire, Pirenne Jacques, Acarli Koray, Allison Michael, Hakeem Abdul, Dhakshinamoorthy Vijayanand, Fedaruk Dzmitry, Rummo Oleg, Kilic Murat, Nordin Arno, Fischer Lutz, Parente Alessandro, Mirza Darius, Bennet William, Tokat Yaman, Faitot Francois, Antonelli Barbara B, Berlakovich Gabriela, Patch David, Berrevoet Frederik, Ribnikar Marija, Gerster Theophile, Savier Eric, Gruttadauria Salvatore, Ericzon Bo-Göran, Valdivieso Andrés, Cuervas-Mons Valentin, Perez Saborido Baltasar, Croner Roland S, De Carlis Luciano, Magini Giulia, Rossi Roberta, Popescu Irinel, Razvan Laze, Schneeberger Stefan, Blokzijl Hans, Llado Laura, Gomez Bravo Miguel Angel, Duvoux Christophe, Mezjlík Vladimír, Oniscu Gabriel C, Pearson Kelsey, Dayangac Murat, Lucidi Valerio, Detry Olivier, Rotellar Fernando, den Hoed Caroline, Polak Wojciech G, Darwish Murad Sarwa, all other contributing centers (www.eltr.org) for the European Liver and Intestine Transplant Association (ELITA)
Аннотация
APPROACH AND RESULTS: Data from all patients who underwent transplantation from 1976 to 2020 was obtained from the European Liver Transplant Registry (ELTR). Patients < 16 years, with secondary BCS or HCC were excluded. Patient survival (PS) and graft survival (GS) before and after 2000 were compared. Multivariate Cox regression analysis identified predictors of PS and GS after 2000. Supplemental data was requested from all ELTR-affiliated centers and received from 44. In all, 808 patients underwent transplantation between 2000 and 2020. One-, 5- and 10-year PS was 84%, 77%, and 68%, and GS was 79%, 70%, and 62%, respectively. Both significantly improved compared to outcomes before 2000 ( p < 0.001). Median follow-up was 50 months and retransplantation rate was 12%. Recipient age (aHR:1.04,95%CI:1.02-1.06) and MELD score (aHR:1.04,95%CI:1.01-1.06), especially above 30, were associated with worse PS, while male sex had better outcomes (aHR:0.63,95%CI:0.41-0.96). Donor age was associated with worse PS (aHR:1.01,95%CI:1.00-1.03) and GS (aHR:1.02,95%CI:1.01-1.03). In 353 patients (44%) with supplemental data, 33% had myeloproliferative neoplasm, 20% underwent TIPS pre-LT, and 85% used anticoagulation post-LT. Post-LT anticoagulation was associated with improved PS (aHR:0.29,95%CI:0.16-0.54) and GS (aHR:0.48,95%CI:0.29-0.81). Hepatic artery thrombosis and portal vein thrombosis (PVT) occurred in 9% and 7%, while recurrent BCS was rare (3%).
CONCLUSIONS: LT for BCS results in excellent patient- and graft-survival. Older recipient or donor age and higher MELD are associated with poorer outcomes, while long-term anticoagulation improves both patient and graft outcomes.