Klinische Padiatrie · 2007
Lower respiratory tract disease in children: constant pathogens - constant management?!
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Wasem S, Weichert S, Walther S, Weigl J A, Puppe W, Ihorst G, Schmitt H-J, Forster J
Аннотация
BACKGROUND: This study analyses the pathogens of acute lower respiratory tract infections (LRI) in children in a German community hospital over six years. Against this background the adoption of new diagnostic and therapeutic guidelines for the LRI management and of RSV-cases in particular is studied.
METHODS: 1054 children aged zero to 36 months hospitalized with LRI were prospectively included in the surveillance studies "Parainfluenzavirus (PIV) and Respiratory syncytial virus (RSV) infections in Germany [PRI.de] 1999-2001" and the "pediatric infectious diseases network on acute respiratory tract infections" [PID-ARI.net] for the time period of October 2002 until June 2005. The nasopharyngeal aspirates (NPA) of these children had been analysed for RSV, PIV 1,2,3 and influenzavirus (IV)-A, -B. In 2003/2004 the national guideline on how to diagnose and treat RSV-disease (bronchiolitis) changed. Data on LRI cases severity and especially those regarding the clinical management of RSV-infections were compared to see differences following the release of the guideline.
RESULTS: 84% of the children were between zero and 24 months old. 34% of the NPA specimens were positive for RSV, 7.7% for PIV 1,2,3 and 4.7% for IV-A, -B. Epidemiological findings did not differ substantially between the two studies. Clinical management of RSV-LRI, especially drug use, did not change except for the lower rate of x-ray examination (p<0.01).
CONCLUSION: The spectrum of causing agents in LRI of children remained quite stable over of six years. Diagnostic and therapeutic concepts remain also stable in a situation where new guidelines were introduced, but not reinforced.
METHODS: 1054 children aged zero to 36 months hospitalized with LRI were prospectively included in the surveillance studies "Parainfluenzavirus (PIV) and Respiratory syncytial virus (RSV) infections in Germany [PRI.de] 1999-2001" and the "pediatric infectious diseases network on acute respiratory tract infections" [PID-ARI.net] for the time period of October 2002 until June 2005. The nasopharyngeal aspirates (NPA) of these children had been analysed for RSV, PIV 1,2,3 and influenzavirus (IV)-A, -B. In 2003/2004 the national guideline on how to diagnose and treat RSV-disease (bronchiolitis) changed. Data on LRI cases severity and especially those regarding the clinical management of RSV-infections were compared to see differences following the release of the guideline.
RESULTS: 84% of the children were between zero and 24 months old. 34% of the NPA specimens were positive for RSV, 7.7% for PIV 1,2,3 and 4.7% for IV-A, -B. Epidemiological findings did not differ substantially between the two studies. Clinical management of RSV-LRI, especially drug use, did not change except for the lower rate of x-ray examination (p<0.01).
CONCLUSION: The spectrum of causing agents in LRI of children remained quite stable over of six years. Diagnostic and therapeutic concepts remain also stable in a situation where new guidelines were introduced, but not reinforced.