Zhonghua nei ke za zhi · 2010
[The efficacy and safety of pemetrexed as monotherapy for Chinese patients with advanced non-small cell lung cancer].
Клиническое исследованиеАннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Zhong Wei, Zhao Jing, Zhang Xiao-tong, Zhang Li, Wang Meng-zhao, Li Long-yun
Аннотация
OBJECTIVE: To assess the outcome of pemetrexed as monotherapy for Chinese patients with advanced non-small cell lung cancer (NSCLC) at the Peking Union Medical College Hospital.
METHODS: From February 2006 to August 2009, 69 patients with advanced NSCLC, including 36 (52.2%) men and 33 (47.8%) women, received pemetrexed monotherapy.Six patients had squamous cell carcinoma, 57 adenocarcinoma, 6 unspecified. Median survival (MS) and progress-free survival (PFS) were calculated using the Kaplan-Meier method.
RESULTS: Adverse events (AEs) were generally mild (grade 1 and 2) and reversible. The most frequent AEs were gastrointestinal adverse events, skin rash, fever and fatigue. Total 5 cases with 3/4 grade AEs were reported, including fever, fatigue, rash, decreased platelets and elevated ALT/AST. The objective tumour response rate and stable disease rate were 10.1% (7/69) and 47.8% (33/69) respectively. Median PFS of all patients was 4.7 months (95%CI 3.0-6.4) and mean overall survival was 14.7 months (95%CI 11.5-17.9).
CONCLUSIONS: Our study suggests that treatment with pemetrexed may be well-tolerated and beneficial for some Chinese patients after failure of prior chemotherapy. The rate of disease control is high and the frequency of 3/4 grade AEs is very low.
METHODS: From February 2006 to August 2009, 69 patients with advanced NSCLC, including 36 (52.2%) men and 33 (47.8%) women, received pemetrexed monotherapy.Six patients had squamous cell carcinoma, 57 adenocarcinoma, 6 unspecified. Median survival (MS) and progress-free survival (PFS) were calculated using the Kaplan-Meier method.
RESULTS: Adverse events (AEs) were generally mild (grade 1 and 2) and reversible. The most frequent AEs were gastrointestinal adverse events, skin rash, fever and fatigue. Total 5 cases with 3/4 grade AEs were reported, including fever, fatigue, rash, decreased platelets and elevated ALT/AST. The objective tumour response rate and stable disease rate were 10.1% (7/69) and 47.8% (33/69) respectively. Median PFS of all patients was 4.7 months (95%CI 3.0-6.4) and mean overall survival was 14.7 months (95%CI 11.5-17.9).
CONCLUSIONS: Our study suggests that treatment with pemetrexed may be well-tolerated and beneficial for some Chinese patients after failure of prior chemotherapy. The rate of disease control is high and the frequency of 3/4 grade AEs is very low.