Giant vulvar neurofibroma in a 19-year-old female: A rare peripheral nerve sheath tumor.

Neurofibromas are benign peripheral nerve sheath tumors that infrequently involve the vulva. Giant vulvar neurofibromas are exceedingly rare, particularly in young patients, and may pose diagnostic challenges due to their unusual location and broad differential diagnosis. We report the case of a 19-year-old female who presented with a slowly enlarging left vulvar mass. Magnetic resonance imaging (MRI) demonstrated a large, well-circumscribed, lobulated soft-tissue lesion with signal characteristics suggestive of a benign peripheral nerve sheath tumor, without invasion of adjacent structures. Complete surgical excision was performed, and histopathological examination confirmed the diagnosis of neurofibroma using S100 immunohistochemical staining. This case highlights the pivotal role of MRI in lesion characterization, surgical planning, and differentiation from other vulvar masses.