Allergy, asthma & immunology research · 2024
Diagnostic Decision Point for IgE-Mediated Wheat Allergy in Children.
СтатьяНазвание и аннотация: Перевод в очереди
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Hwang Yoonha, Kim Jihyun, Ahn Kangmo, Jeong Kyunguk, Lee Sooyoung, Hong Soo-Jong, Jeon You Hoon, Kim Yoon Hee, Shin Meeyong, Song Tae Won, Jung Minyoung, Kim Minji, Min Taek Ki, Lee Ji Young, Kim Min Jung, Lee Yong Ju, Lee Jeongmin, Park Young A, Jang Gwang Cheon, Ahn Young Min, Lee So-Yeon, Kim Jeong Hee, Food Allergy and Atopic Dermatitis (FAAD) study Group in the Korean Academy of Pediatric Allergy and Respiratory Disease
Аннотация
The diagnostic decision point can help diagnose food allergies while reducing the need for oral food challenge (OFC) tests. We performed a multicenter survey of children aged 0-7 years from January 1, 2018 to March 31, 2022. A total of 231 children were recruited from 18 institutions. Wheat allergy (WA) or non-wheat allergy (NWA) was determined on the basis of OFC results and symptoms. There were no differences in age, sex, family history of allergy or allergic comorbidities between the WA and NWA groups. According to receiver operating characteristic analysis for wheat-specific immunoglobulin E (IgE), the optimal cutoff value, positive decision point, and negative decision point were 10.2, 33.5, and 0.41 kU/L, respectively. For the ω-5 gliadin-specific IgE, their values were 0.69, 3.88, and 0.01 kU/L, respectively. This new diagnostic decision point may be used to diagnose WA in Korean children.