[Clinico-morphological characteristics of liver diseases associated with nonconjugated hyperbilirubinemia syndrome].

Altogether 98 puncture liver biopsies taken from patients with a syndrome of nonconjugated hyperbilirubinemia are examined in light and electron microscope. It is established that this syndrome frequently develops in inflammatory liver diseases, notably in primary (viral, alcoholic, medicinal) and secondary (nonspecific reactive) hepatitis. Both light and electron-microscopic investigation of liver puncture biopsies allows determining the type of a pathological process in the liver, to specify its etiology and to study the structural basis of bilirubin metabolic disorders in the liver. The mechanism of these metabolic disorders is complex and includes alteration of the bilirubin seizure by a sinusoidal hepatocyte pole, its conjugation and formation of ultimate metabolites.