[The effectiveness of urea in the management of chronic hyponatremia and its impact on nutritional status].

Introduction: the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of chronic hyponatremia. Persistent hyponatremia has been associated with multiple long-term complications. Consequently, there is increasing interest in identifying safe and effective strategies for the long-term management of this condition. Case report: we report the case of a middle-aged woman with underlying pulmonary disease and multiple hospital admissions during the previous year, who presented with moderate chronic hyponatremia meeting the diagnostic criteria for SIADH, as well as disease-related malnutrition. Discussion: given her history of cancer treatment-related sequelae, outpatient treatment with oral urea was initiated. During follow-up, the patient achieved sustained eunatremia without adverse effects, and showed no deterioration in nutritional status, as assessed by bioelectrical impedance analysis.