Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
Prognostic Impact of Pacemaker Implantation in Transcatheter Aortic Valve Replacement With Self-Expanding Prosthesis.
СтатьяМногоцентровое исследованиеНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Felice Francesco De, Paolucci Luca, Nazzaro Marco Stefano, Musto Carmine, Chin Diana, Stio Rocco, Pennacchi Mauro, Gabrielli Domenico, Massussi Mauro, Chizzolla Giuliano, Adamo Marianna, Carlo Marco De, Giannini Cristina, Costa Giulia, Sisinni Antonio, Testa Luca, Bellini Barbara, Montorfano Matteo, Bruschi Giuseppe, Merlanti Bruno, Poli Arnaldo, Ferrara Erica, Attisano Tiziana, Palmerini Tullio, Regazzoli Damiano
Аннотация
BACKGROUND: With the progressively increasing number of low-risk patients undergoing transcatheter aortic valve replacement (TAVR), the number of those who will be long-time pacemaker (PM) carriers is expected to increase. To date, conflicting data is available regarding the association between PM and mortality following TAVR.
AIMS: To investigate the association between PM and mortality in patients undergoing TAVR with self-expandable bio-prosthesis.
METHODS: Patients undergoing TAVR between 2007 and 2014 in 10 Italian centers were considered. Two analyses were performed: one comparing patients with and without pre-TAVR PM (primary) and one comparing those with and without post-TAVR PM (secondary). The primary endpoint was all-cause mortality; the secondary endpoint was re-hospitalization to the cardiac ward. Clinical outcomes were assessed at the longest available follow-up.
RESULTS: Overall, 1779 patients were included in the primary analysis and 1465 in the secondary one. Pre-TAVR PM implantation was not associated with an increased risk of all cause death in both the primary (adj. HR 0.93, 95% CI 0.76-1.13; p = 0.475) and secondary analysis (adj. HR 0.83, 95% CI 0.71-0.98; p = 0.029). Regarding hospitalization to cardiac ward, pre-TAVR PM was not associated with the outcome (adj. HR 1.10, 95% CI 0.85-1.42, p = 0.254), while post-TAVR PM implantation was related with an increased risk (adj. HR 1.94, 95% CI 1.56-2.41; p < 0.001).
CONCLUSIONS: PM implantation is not associated with an increased risk of mortality in patients undergoing TAVR.
AIMS: To investigate the association between PM and mortality in patients undergoing TAVR with self-expandable bio-prosthesis.
METHODS: Patients undergoing TAVR between 2007 and 2014 in 10 Italian centers were considered. Two analyses were performed: one comparing patients with and without pre-TAVR PM (primary) and one comparing those with and without post-TAVR PM (secondary). The primary endpoint was all-cause mortality; the secondary endpoint was re-hospitalization to the cardiac ward. Clinical outcomes were assessed at the longest available follow-up.
RESULTS: Overall, 1779 patients were included in the primary analysis and 1465 in the secondary one. Pre-TAVR PM implantation was not associated with an increased risk of all cause death in both the primary (adj. HR 0.93, 95% CI 0.76-1.13; p = 0.475) and secondary analysis (adj. HR 0.83, 95% CI 0.71-0.98; p = 0.029). Regarding hospitalization to cardiac ward, pre-TAVR PM was not associated with the outcome (adj. HR 1.10, 95% CI 0.85-1.42, p = 0.254), while post-TAVR PM implantation was related with an increased risk (adj. HR 1.94, 95% CI 1.56-2.41; p < 0.001).
CONCLUSIONS: PM implantation is not associated with an increased risk of mortality in patients undergoing TAVR.
Предметные рубрики MeSH
AgedAged, 80 and overFemaleHumansMaleAortic ValveAortic Valve StenosisArrhythmias, CardiacBioprosthesisCardiac Pacing, ArtificialHeart Valve ProsthesisItalyPacemaker, ArtificialPatient ReadmissionProsthesis DesignRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment Outcome