Acetylcholine receptor antibody-positive myasthenia gravis and Kennedy's disease overlap syndrome: a case report and literature review.

OBJECTIVE

To investigate the clinical characteristics and electromyographic findings of a patient with acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG) overlapping with Kennedy's disease (KD), aiming to improve clinicians' recognition of this rare overlap syndrome and explore potential comorbid mechanisms.

METHODS

The clinical presentation, laboratory results, and neurophysiological features of one case with AChR antibody-positive MG and KD were analyzed. A literature review of MG overlapping with KD was performed.

CONCLUSION

Neurophysiological findings and androgen receptor gene testing results were consistent with a diagnosis of KD. Therefore, the patient was definitively diagnosed with overlap syndrome of AChR antibody-positive MG and KD. A literature review identified only four previously reported cases of KD patients exhibiting myasthenic features; however, all were AChR antibody-negative.