Future science OA · 2026
Severe numbness of the mouth and tongue induced by piperacillin/tazobactam: a rare case report.
СтатьяНазвание и аннотация: Перевод в очереди
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Huang Xinqi, Liu Wanlin, Tan Bo, Shi Lichuan, Huang Yongliang, Wang Shuting, Yin Nianqing, Li Yi, Zheng Liutao, Dai Yanli
Аннотация
BACKGROUND: Severe oral and tongue numbness induced by piperacillin/tazobactam is extremely rare.
RESULTS: A 58-year-old man with bacterial pneumonia developed oral and tongue numbness, dyspnea, and pruritus approximately 4 minutes after intravenous infusion of piperacillin/tazobactam. Based on adverse drug reaction causality assessment, this event was identified as a previously unreported severe adverse drug reaction.
DISCUSSION: This case suggests that during clinical use of piperacillin/tazobactam, clinicians should remain vigilant for rare but severe adverse drug reactions even when skin testing is negative, and strengthen medication monitoring to ensure medication safety.
RESULTS: A 58-year-old man with bacterial pneumonia developed oral and tongue numbness, dyspnea, and pruritus approximately 4 minutes after intravenous infusion of piperacillin/tazobactam. Based on adverse drug reaction causality assessment, this event was identified as a previously unreported severe adverse drug reaction.
DISCUSSION: This case suggests that during clinical use of piperacillin/tazobactam, clinicians should remain vigilant for rare but severe adverse drug reactions even when skin testing is negative, and strengthen medication monitoring to ensure medication safety.