Severe numbness of the mouth and tongue induced by piperacillin/tazobactam: a rare case report.

BACKGROUND

Severe oral and tongue numbness induced by piperacillin/tazobactam is extremely rare.

RESULTS

A 58-year-old man with bacterial pneumonia developed oral and tongue numbness, dyspnea, and pruritus approximately 4 minutes after intravenous infusion of piperacillin/tazobactam. Based on adverse drug reaction causality assessment, this event was identified as a previously unreported severe adverse drug reaction.

DISCUSSION: This case suggests that during clinical use of piperacillin/tazobactam, clinicians should remain vigilant for rare but severe adverse drug reactions even when skin testing is negative, and strengthen medication monitoring to ensure medication safety.