Respiratory medicine · 2026
Effects of photobiomodulation by infrared LED-therapy on improving cardiopulmonary functions and hematologic parameters in patients with community-acquired pneumonia (CAP).
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Pereira Pâmela Camila, de Lima Carlos José, Fernandes Adriana Barrinha, Carvalho Henrique Cunha, Alves Leandro Procópio, Zângaro Renato Amaro, Villaverde Antonio Balbin
Аннотация
BACKGROUND: Community-acquired pneumonia (CAP) is associated with restrictive pulmonary dysfunction and ventilation-perfusion imbalance. This study evaluated the effects of photobiomodulation (PBM) on pulmonary function and hematological parameters in CAP patients.
METHODS: This randomized clinical trial, registered in the Brazilian Registry of Clinical Trials (ReBEC: UTN U1111-1229-1296; June 5, 2019), included 30 patients with CAP randomly allocated to two groups: an LED group receiving 940-nm PBM plus conventional therapy and a control group receiving conventional therapy alone (antibiotics and physiotherapy). PBM was delivered using a vest containing 300 near-infrared LEDs applied to the anterior thoracic and abdominal regions for 15 min daily over 7 consecutive days. Data were anonymized prior to analysis, and statistical comparisons were performed using paired and unpaired two-tailed Student's t-tests.
RESULTS: The PBM adjunct to the conventional therapy improved the pulmonary recovery process and the clinical status, reduced respiratory symptoms, decreased hospital stay (9.3 vs 7.3 days) (p = 0.0015, g = -1.25), inducing an increase in peripheral oxygen saturation (SpO2) (88.3 to 98%) (p = 0.0001; g = 1.70), maximum inspiratory pressure (MIP) (-40 to -65.3 cmH2O) (p < 0.0001; g = -1.37), forced vital capacity (FVC) (62% to 80%) (p < 0.0021; g = 1.10), improvement in hematological data erythrocytes (3.51 to 5.54 mm3) (p = 0.0071; g = 1.69), hematocrit (32.60 to 39.14 %) (p = 0.0105; g = 0.66), and typical lymphocytes (40 to 31%) (p = 0.0120; g = -1.22), as well as, pulmonary auscultation (6.1 to 3.1 days) (p < 0.0001).
CONCLUSION: PBM treatment adjunctive to conventional therapy improved the pulmonary and clinical status of patients, reduced respiratory symptoms, and shortened the length of hospital stay.
METHODS: This randomized clinical trial, registered in the Brazilian Registry of Clinical Trials (ReBEC: UTN U1111-1229-1296; June 5, 2019), included 30 patients with CAP randomly allocated to two groups: an LED group receiving 940-nm PBM plus conventional therapy and a control group receiving conventional therapy alone (antibiotics and physiotherapy). PBM was delivered using a vest containing 300 near-infrared LEDs applied to the anterior thoracic and abdominal regions for 15 min daily over 7 consecutive days. Data were anonymized prior to analysis, and statistical comparisons were performed using paired and unpaired two-tailed Student's t-tests.
RESULTS: The PBM adjunct to the conventional therapy improved the pulmonary recovery process and the clinical status, reduced respiratory symptoms, decreased hospital stay (9.3 vs 7.3 days) (p = 0.0015, g = -1.25), inducing an increase in peripheral oxygen saturation (SpO2) (88.3 to 98%) (p = 0.0001; g = 1.70), maximum inspiratory pressure (MIP) (-40 to -65.3 cmH2O) (p < 0.0001; g = -1.37), forced vital capacity (FVC) (62% to 80%) (p < 0.0021; g = 1.10), improvement in hematological data erythrocytes (3.51 to 5.54 mm3) (p = 0.0071; g = 1.69), hematocrit (32.60 to 39.14 %) (p = 0.0105; g = 0.66), and typical lymphocytes (40 to 31%) (p = 0.0120; g = -1.22), as well as, pulmonary auscultation (6.1 to 3.1 days) (p < 0.0001).
CONCLUSION: PBM treatment adjunctive to conventional therapy improved the pulmonary and clinical status of patients, reduced respiratory symptoms, and shortened the length of hospital stay.