Infectious diseases now · 2025
Computed tomography for the diagnosis of HIV-associated gastro-intestinal histoplasmosis.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Droz-Bartholet Domitille, Garzelli Lorenzo, Françoise Ugo, Aboikoni Alolia, Adenis Antoine, Zappa Magaly
Аннотация
INTRODUCTION: Disseminated histoplasmosis is one of the leading opportunistic infections among people living with human immunodeficiency virus (PLHIV) in Latin America. Intestinal involvement is common, but its computed tomography findings have not been properly described. We aimed to provide a computed tomography description of histoplasmosis intestinal involvement.
PATIENTS AND METHODS: We performed a retrospective observational study of patients with disseminated histoplasmosis and proven intestinal involvement.
RESULTS: A total of 18 patients with an available contrast-enhanced abdominal computed tomography (8 women, mean age 44 years) were included. Seventeen had intestinal parietal thickening (94 %), with a mean thickening of 14 mm, unifocal or multifocal, frequently circumferential (71 %). The most commonly affected segments were the cecum and right colon in 13/17 (76 %) of patients each. Adenomegaly was constant, mostly homogeneous.
CONCLUSION: These computed tomography features in patients with advanced HIV disease may be key findings for an early diagnosis in the absence of proven histoplasmosis.
PATIENTS AND METHODS: We performed a retrospective observational study of patients with disseminated histoplasmosis and proven intestinal involvement.
RESULTS: A total of 18 patients with an available contrast-enhanced abdominal computed tomography (8 women, mean age 44 years) were included. Seventeen had intestinal parietal thickening (94 %), with a mean thickening of 14 mm, unifocal or multifocal, frequently circumferential (71 %). The most commonly affected segments were the cecum and right colon in 13/17 (76 %) of patients each. Adenomegaly was constant, mostly homogeneous.
CONCLUSION: These computed tomography features in patients with advanced HIV disease may be key findings for an early diagnosis in the absence of proven histoplasmosis.