Relationship between age and severity of cognitive impairment at diagnosis for early-onset and late-onset Alzheimer's disease: Comparison of LEADS and ADNI.
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Hammers Dustin B, Eloyan Ani, Thangarajah Maryanne, Taurone Alexander, Gao Sujuan, Beckett Laurel, Kirby Kala, Dage Jeffrey L, Nudelman Kelly, Aisen Paul, Reman Rema, Vemuri Prashanthi, La Joie Renaud, Touroutoglou Alexandra, Atri Alireza, Clark David, Day Gregory S, Duara Ranjan, Graff-Radford Neill R, Honig Lawrence S, Jones David T, Masdeu Joseph C, Mendez Mario F, Womack Kyle, Musiek Erik, Onyike Chiadi U, Riddle Meghan, Grant Ian, Rogalski Emily, Johnson Erik C B, Salloway Steven, Sha Sharon J, Turner Raymond Scott, Wingo Thomas S, Wolk David A, Carrillo Maria C, Dickerson Bradford C, Rabinovici Gil D, Apostolova Liana G, LEADS Consortium, Alzheimer's Disease Neuroimaging Initiative
Аннотация
METHODS: A series of linear spline regression models was conducted across baseline cognitive data from 325 EOAD and 314 LOAD participants, after accounting for education, sex, and apolipoprotein ε4 status.
RESULTS: Significant differences existed in the relationship between baseline age and cognitive performance between EOAD and LOAD samples for Processing Speed/Attention, Executive Functioning, and Episodic Immediate Memory. Younger participants from both EOAD and LOAD groups performed disproportionately worse on non-amnestic cognitive domains, with this occurring to a greater extent in EOAD than LOAD.
DISCUSSION: In the age of disease-modifying treatments, results highlight the importance of assessing for cognitive declines in individuals starting much earlier than age 65.
HIGHLIGHTS: Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) participants each displayed cognitive impairments relative to same-aged peers across most domains. Both groups displayed positive relationships between impairment among non-amnestic cognitive domains and baseline age. This relationship displayed a significantly greater effect in EOAD than LOAD, with domains of Processing Speed/Attention and Executive Functioning skills being the most pronounced. Of those participants developing AD, age displayed a disproportionate impact on their symptom onset.