JACC. Basic to translational science · 2019
Sonodynamic Therapy Suppresses Neovascularization in Atherosclerotic Plaques via Macrophage Apoptosis-Induced Endothelial Cell Apoptosis.
СтатьяНазвание и аннотация: Перевод в очереди
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Yao Jianting, Gao Weiwei, Wang Yu, Wang Lu, Diabakte Kamal, Li Jinyang, Yang Jiemei, Jiang Yongxing, Liu Yuerong, Guo Shuyuan, Zhao Xuezhu, Cao Zhengyu, Chen Xi, Li Qiannan, Zhang Haiyu, Wang Wei, Tian Zhen, Li Bicheng, Tian Fang, Wu Guodong, Pourteymour Shirin, Huang Xi, Tan Fancheng, Cao Xiaoru, Yang Zhuowen, Li Kang, Zhang Yan, Li Yong, Zhang Zhiguo, Jin Hong, Tian Ye
Аннотация
During atherosclerosis plaque progression, pathological intraplaque angiogenesis leads to plaque rupture accompanied by thrombosis, which is probably the most important cause of arteries complications such as cerebral and myocardial infarction. Even though few treatments are available to mitigate plaque rupture, further investigation is required to develop a robust optimized therapeutic method. In this study using rabbit and mouse atherosclerotic models, sinoporphyrin sodium (DVDMS)-mediated sonodynamic therapy reduced abnormal angiogenesis and plaque rupture. Briefly, DVDMS is injected to animals, and then the plaque was locally exposed to pulse ultrasound for a few minutes. Furthermore, a small size clinical trial was conducted on patients with atherosclerosis. Notably, a significant reduction of arterial inflammation and angiogenesis was recorded following a short period of DVDMS-mediated sonodynamic therapy treatment. This beneficial outcome was almost equivalent to the therapeutic outcome after 3-month intensive statin treatment.