Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19.
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Queiroz Maria Alice Freitas, Santiago Angélica Menezes, Brito Wandrey Roberto Dos Santos, Pereira Keise Adrielle Santos, de Brito William Botelho, Torres Maria Karoliny da Silva, Lopes Jeferson da Costa, Dos Santos Erika Ferreira, da Costa Flávia Póvoa, de Sarges Kevin Matheus Lima, Cantanhede Marcos Henrique Damasceno, de Brito Mioni Thieli Figueiredo Magalhães, da Silva Andréa Luciana Soares, Leite Mauro de Meira, Viana Maria de Nazaré do Socorro de Almeida, Rodrigues Fabíola Brasil Barbosa, da Silva Rosilene, Viana Giselle Maria Rachid, Chaves Tânia do Socorro Souza, Veríssimo Adriana de Oliveira Lameira, Carvalho Mayara da Silva, Henriques Daniele Freitas, Dos Santos Carla Pinheiro, Nunes Juliana Abreu Lima, Costa Iran Barros, Amoras Ednelza da Silva Graça, Lima Sandra Souza, Cayres-Vallinoto Izaura Maria Vieira, Brasil-Costa Igor, Quaresma Juarez Antônio Simões, Falcão Luiz Fábio Magno, Dos Santos Eduardo José Melo, Vallinoto Antonio Carlos Rosário
Аннотация
METHODS: Blood samples from 385 individuals (208 with acute COVID-19 and 117 post-COVID-19) were subjected to real-time PCR genotyping. Plasma measurements of MBL and cytokines were performed by enzyme-linked immunosorbent assay and flow cytometry, respectively.
RESULTS: The frequencies of the polymorphic MBL2 genotype (OO) and allele (O) were higher in patients with severe COVID-19 (p< 0.05). The polymorphic genotypes (AO and OO) were associated with lower MBL levels (p< 0.05). IL-6 and TNF-α were higher in patients with low MBL and severe COVID-19 (p< 0.05). No association of polymorphisms, MBL levels, or cytokine levels with long COVID was observed.
DISCUSSION: The results suggest that, besides MBL2 polymorphisms promoting a reduction in MBL levels and therefore in its function, they may also contribute to the development of a more intense inflammatory process responsible for the severity of COVID-19.