Frontiers in pediatrics · 2026
Association between glucolipid metabolic indicators and the risk of suspected precocious puberty in children living with obesity: a retrospective cohort study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hao Tingting, Li Yifan, Zhang Qingmei
Аннотация
OBJECTIVE: To investigate the association between glucolipid metabolic indicators and suspected precocious puberty (PP) in children living with obesity.
METHODS: This retrospective observational study initially included 100 children with obesity (BMI ≥95th percentile) hospitalized between March 2022 and June 2025. Sexual development was assessed by Tanner staging. Children were categorized into suspected PP (n = 32) and non-PP (n = 68) groups based on age-specific criteria. After excluding 5 girls in the suspected PP group who had isolated pubic hair without breast development (premature adrenarche), the final analysis included 95 children (suspected PP: n = 27; non-PP: n = 68). Fasting plasma glucose (FPG), fasting insulin (FINS), HOMA-IR, triglycerides (TG), total cholesterol (TC), HDL-C, LDL-C, uric acid (UA), sex hormones, and bone age advancement were compared. Spearman correlation and multivariable logistic regression (adjusted for age, sex, and waist-to-height ratio) were performed. Sensitivity analyses were conducted excluding children with basal LH >0.5 IU/L in the control group.
RESULTS: The suspected PP group had significantly higher FPG, FINS, HOMA-IR, TG, TC, LDL-C, uric acid, sex hormones, and bone age advancement (1.88 ± 0.64 vs. 0.86 ± 0.48 years), and lower HDL-C (all P < 0.05). Correlation analysis showed positive associations between Tanner stage/bone age and all metabolic indicators except HDL-C. Logistic regression identified HOMA-IR (OR = 2.38), TG (OR = 2.07), and uric acid (OR = 1.71) as independent risk factors, and HDL-C (OR = 0.56) as protective (all P < 0.05). Excluding control children with LH > 0.5 IU/L (n = 5 remaining) showed similar trends but lacked power.
CONCLUSION: Suspected precocious puberty in children living with obesity is closely associated with insulin resistance, elevated triglycerides, and hyperuricemia, whereas higher HDL-C is protective. These findings highlight the importance of early metabolic monitoring in this inpatient population, with the caveat that the cohort represents a selected hospitalized sample.
METHODS: This retrospective observational study initially included 100 children with obesity (BMI ≥95th percentile) hospitalized between March 2022 and June 2025. Sexual development was assessed by Tanner staging. Children were categorized into suspected PP (n = 32) and non-PP (n = 68) groups based on age-specific criteria. After excluding 5 girls in the suspected PP group who had isolated pubic hair without breast development (premature adrenarche), the final analysis included 95 children (suspected PP: n = 27; non-PP: n = 68). Fasting plasma glucose (FPG), fasting insulin (FINS), HOMA-IR, triglycerides (TG), total cholesterol (TC), HDL-C, LDL-C, uric acid (UA), sex hormones, and bone age advancement were compared. Spearman correlation and multivariable logistic regression (adjusted for age, sex, and waist-to-height ratio) were performed. Sensitivity analyses were conducted excluding children with basal LH >0.5 IU/L in the control group.
RESULTS: The suspected PP group had significantly higher FPG, FINS, HOMA-IR, TG, TC, LDL-C, uric acid, sex hormones, and bone age advancement (1.88 ± 0.64 vs. 0.86 ± 0.48 years), and lower HDL-C (all P < 0.05). Correlation analysis showed positive associations between Tanner stage/bone age and all metabolic indicators except HDL-C. Logistic regression identified HOMA-IR (OR = 2.38), TG (OR = 2.07), and uric acid (OR = 1.71) as independent risk factors, and HDL-C (OR = 0.56) as protective (all P < 0.05). Excluding control children with LH > 0.5 IU/L (n = 5 remaining) showed similar trends but lacked power.
CONCLUSION: Suspected precocious puberty in children living with obesity is closely associated with insulin resistance, elevated triglycerides, and hyperuricemia, whereas higher HDL-C is protective. These findings highlight the importance of early metabolic monitoring in this inpatient population, with the caveat that the cohort represents a selected hospitalized sample.