Characteristics of Young Children Hospitalized With Acute Respiratory Failure From Infection With Respiratory Syncytial Virus, SARS-CoV-2, or Both, November 2023-March 2024.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Simeone Regina M, Newhams Margaret M, Zambrano Laura D, Calixte Jemima M, Lindsey Katherine, Orzel-Lockwood Amber, Payne Amanda B, Halasa Natasha B, Kamidani Satoshi, Maddux Aline B, Chiotos Kathleen, Crandall Hillary, Schuster Jennifer E, Zerr Danielle M, Martin Lora M, Cameron Melissa A, Irby Katherine, Gertz Shira J, Shein Steven L, Nofziger Ryan A, Bhumbra Samina S, Hume Janet R, Kong Michele, Maamari Mia, Coates Bria M, Guzman-Cottrill Judith A, Staat Mary Allen, Connors Thomas J, Zinter Matt S, Chauhan Jigar C, Bradford Tamara T, Wellnitz Kari, Campbell Angela P, Randolph Adrienne G, Overcoming COVID-19 Investigators
Аннотация
METHODS: We used data from a US pediatric respiratory virus hospitalization surveillance network including children with ICU admission for acute respiratory failure (receiving high-flow oxygen or mechanical ventilation) with RSV and/or SARS-CoV-2 during November 2023-March 2024. Demographic, clinical characteristics, and hospitalization outcomes were stratified by a positive test for RSV, SARS-CoV-2, or both viruses, and compared using chi-squared or Kruskal-Wallis tests. Multivariable analyses assessed independent associations between outcomes and infection.
RESULTS: Overall, 1406 children were included: 1253 (89.1%) for RSV, 105 (7.5%) for COVID-19, and 48 (3.4%) with RSV + SARS-CoV-2 detected. Children with RSV or RSV + SARS-CoV-2 had lower median ages (3.9 and 5.4 months, respectively) compared with those with SARS-CoV-2 (8.8 months; P < .001). Twenty percent of children with RSV and 43.8% with COVID-19 had an underlying medical condition. Among infants aged <1 year for whom preterm status was available, 31.5% with RSV and 50% with COVID-19 had either prematurity or a comorbidity. Children with SARS-CoV-2 were more likely to require invasive mechanical ventilation, receive vasoactive infusions, and die compared with RSV with and without SARS-CoV-2.
CONCLUSIONS: Critically ill children <2 years of age infected with SARS-CoV-2 had more severe illness presentation and outcomes and were older compared with those with RSV and RSV + SARS-CoV-2 codetection. Most children were previously healthy, highlighting the need for prevention measures.