International ophthalmology · 2026
Relationship between albuminuria and primary open angle glaucoma in patients attending a Nigerian tertiary hospital.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Sule Ademola Ayoda, Adenekan Adetunji Olusesan, Alabi Adegboyega Sunday, Ajie Obiefuna, Idowu Oluwatobi, Anikwenwa Judith Ogechi, Musa Kareem Olatunbosun, Onakoya Adeola Olukorede
Аннотация
PURPOSE: Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness globally. Emerging evidence suggests glaucoma is a vasculopathy with associated systemic microvascular dysfunction. A known feature of endothelial dysfunction is transudation, typified by albuminuria. This aimed to determine the relationship between POAG and albuminuria in patients attending a Nigerian tertiary hospital with a view to enhancing the evaluation and management of POAG patients for blindness prevention, particularly in resource-limited settings.
METHODS: This hospital-based, comparative cross-sectional study included 210 adults: 105 POAG patients and 105 age-and sex-matched non-glaucomatous participants. Data on demographics and medical history were collected using an interviewer-administered questionnaire. Blood samples were analyzed for fasting blood sugar, lipid profile, and estimated glomerular filtration rate (GFR). Spot urine samples were collected to determine albuminuria using the urinary albumin-to-creatinine ratio (UACR, mg/g), based on measurements of urinary albumin and creatinine.
RESULTS: A total of 210 patients were enrolled. These included 45 males and 60 females in each study and control group (male-to-female ratio of 1:1.3). The mean age of POAG participants was 43.91 ± 14.8 years. Among POAG participants, 69 (65.7%) had mild, 26 (24.8%) had moderate, and 10 (9.5%) had severe POAG. A significantly higher proportion of albuminuria was observed in the POAG group (8 patients, 7.6%) compared to the non-glaucoma group (3 patients, 2.9%) (p = 0.049). The odds of albuminuria were nearly three times higher in participants with severe POAG compared to those with mild POAG (OR = 2.993; 95% CI, 1.003-7.574; p = 0.048), and participants with POAG were approximately 2.5 times more likely to have albuminuria compared to the non-glaucoma group (OR = 2.483; 95% CI, 1.071-4.552; p = 0.042). Median UACR was significantly higher in the POAG group (7.69 mg/g; interquartile range [6.2-10.3]) compared to the non-glaucoma group (3.83 mg/g; range [1.7-9.3]) (p < 0.001).
CONCLUSION: This study demonstrated a significant association between POAG and albuminuria, with increasing severity of POAG correlating with higher odds of albuminuria. These findings suggest that albuminuria could serve as a systemic marker of disease severity in POAG. Early identification and monitoring of albuminuria in glaucoma patients may improve disease management and outcomes, potentially reducing the incidence of blindness.
METHODS: This hospital-based, comparative cross-sectional study included 210 adults: 105 POAG patients and 105 age-and sex-matched non-glaucomatous participants. Data on demographics and medical history were collected using an interviewer-administered questionnaire. Blood samples were analyzed for fasting blood sugar, lipid profile, and estimated glomerular filtration rate (GFR). Spot urine samples were collected to determine albuminuria using the urinary albumin-to-creatinine ratio (UACR, mg/g), based on measurements of urinary albumin and creatinine.
RESULTS: A total of 210 patients were enrolled. These included 45 males and 60 females in each study and control group (male-to-female ratio of 1:1.3). The mean age of POAG participants was 43.91 ± 14.8 years. Among POAG participants, 69 (65.7%) had mild, 26 (24.8%) had moderate, and 10 (9.5%) had severe POAG. A significantly higher proportion of albuminuria was observed in the POAG group (8 patients, 7.6%) compared to the non-glaucoma group (3 patients, 2.9%) (p = 0.049). The odds of albuminuria were nearly three times higher in participants with severe POAG compared to those with mild POAG (OR = 2.993; 95% CI, 1.003-7.574; p = 0.048), and participants with POAG were approximately 2.5 times more likely to have albuminuria compared to the non-glaucoma group (OR = 2.483; 95% CI, 1.071-4.552; p = 0.042). Median UACR was significantly higher in the POAG group (7.69 mg/g; interquartile range [6.2-10.3]) compared to the non-glaucoma group (3.83 mg/g; range [1.7-9.3]) (p < 0.001).
CONCLUSION: This study demonstrated a significant association between POAG and albuminuria, with increasing severity of POAG correlating with higher odds of albuminuria. These findings suggest that albuminuria could serve as a systemic marker of disease severity in POAG. Early identification and monitoring of albuminuria in glaucoma patients may improve disease management and outcomes, potentially reducing the incidence of blindness.