Biomarkers in medicine · 2026
Prognostic value of the CALLY index in patients undergoing transcatheter aortic valve implantation.
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Aslan Serkan, Demir Ali Rıza, Demirci Gökhan, Aydın Emre, Aydın Merve Yükselen, Uygur Begüm, Ağuş Hicaz Zencirkiran, Güler Arda, Kahraman Serkan, Güler Gamze Babür, Ertürk Mehmet
Аннотация
AIMS: The C-reactive protein-albumin-lymphocyte (CALLY) index is a composite biomarker reflecting inflammation, nutritional status, and immune response. This study evaluated the association of the CALLY index with all-cause mortality in patients undergoing transcatheter aortic valve implantation (TAVI).
METHODS: In this retrospective study, 733 consecutive TAVI patients were classified as Low-CALLY (≤0.95) or High-CALLY (>0.95) using an ROC-derived cutoff. The primary endpoint was all-cause mortality during follow-up. Predictors of mortality were assessed using Cox proportional hazards regression, while discriminative performance and survival were evaluated by ROC and Kaplan-Meier analyses.
RESULTS: Mortality was higher in the Low-CALLY group than in the High-CALLY group (57.1% vs. 19.3%; p < 0.001). The CALLY index showed moderate discrimination for mortality (AUC 0.719; 95% CI 0.681-0.757; p < 0.001). In multivariable Cox regression, Low CALLY remained independently associated with mortality in the clinical model (HR 3.31; 95% CI 2.49-4.39), STS-PROM-adjusted model (HR 3.16; 95% CI 2.37-4.22), and EuroSCORE II-adjusted model (HR 3.72; 95% CI 2.84-4.88) (all p < 0.001). Kaplan-Meier analysis showed lower survival in the Low-CALLY group (log-rank p < 0.001).
CONCLUSION: The CALLY index was independently associated with mortality after TAVI and may complement established risk scores in pre-procedural risk stratification.
METHODS: In this retrospective study, 733 consecutive TAVI patients were classified as Low-CALLY (≤0.95) or High-CALLY (>0.95) using an ROC-derived cutoff. The primary endpoint was all-cause mortality during follow-up. Predictors of mortality were assessed using Cox proportional hazards regression, while discriminative performance and survival were evaluated by ROC and Kaplan-Meier analyses.
RESULTS: Mortality was higher in the Low-CALLY group than in the High-CALLY group (57.1% vs. 19.3%; p < 0.001). The CALLY index showed moderate discrimination for mortality (AUC 0.719; 95% CI 0.681-0.757; p < 0.001). In multivariable Cox regression, Low CALLY remained independently associated with mortality in the clinical model (HR 3.31; 95% CI 2.49-4.39), STS-PROM-adjusted model (HR 3.16; 95% CI 2.37-4.22), and EuroSCORE II-adjusted model (HR 3.72; 95% CI 2.84-4.88) (all p < 0.001). Kaplan-Meier analysis showed lower survival in the Low-CALLY group (log-rank p < 0.001).
CONCLUSION: The CALLY index was independently associated with mortality after TAVI and may complement established risk scores in pre-procedural risk stratification.