The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2026
Polished but pointless? Assessing the potential of gold and silver-alloy IUDs versus copper-only devices in a large multinational cohort (EURAS-LCS12).
Сравнительное исследованиеСтатьяМногоцентровое исследованиеНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Boehnke T, Eggebrecht L, Rizzo M, Klinghardt M, Heinemann K
Аннотация
BACKGROUND: Some copper intrauterine devices (IUDs) contain gold or silver to enhance durability, ultrasound visibility, and reduce infection risk, though evidence thereof is limited.
OBJECTIVE: To evaluate potential benefits of copper-gold and copper-silver alloys over copper-only IUDs regarding the occurrence of product technical complaints (PTC), pelvic inflammatory disease (PID), and unintended pregnancy.
METHODS: This exploratory analysis used data from the ongoing EURAS-LCS12 study, comparing outcomes across IUD types using descriptive statistics and incidence rates with 95% confidence intervals (CI).
RESULTS: Among 28,280 copper IUD users, copper-only IUDs were most common (63.4%) followed by copper-silver (32.4%) and copper-gold IUDs (4.2%). Overall, 114 PTC were reported within a follow-up time up to 113 months. The incidence of PTC was highest in copper-gold IUD users (copper-gold: 1.20 [95% CI, 0.86-1.70]; copper-silver: 0.21 [95% CI, 0.15-0.29]; copper-only: 0.09 [95% CI, 0.07-0.13] per 100 women-years [WY]). In total, we observed 28 events of PID with no substantial differences between groups (copper-only: 0.48 [95% CI, 0.29-0.75]; copper-silver: 0.40 [95% CI, 0.17-0.79]; copper-gold: 0.35 [95% CI, 0.01-2.00] per 1,000 WY). The incidence of unintended pregnancy was similar across groups (copper-gold: 0.46 [95% CI, 0.24-0.78]; copper-only: 0.43 [95% CI, 0.37-0.50]; copper-silver: 0.35 [95% CI, 0.27-0.45] per 100 WY).
CONCLUSION: We did not observe any differences in the clinical outcomes PID and unintended pregnancy between copper-only, copper-silver and copper-gold IUDs. However, copper-gold IUD users experienced more PTC.
OBJECTIVE: To evaluate potential benefits of copper-gold and copper-silver alloys over copper-only IUDs regarding the occurrence of product technical complaints (PTC), pelvic inflammatory disease (PID), and unintended pregnancy.
METHODS: This exploratory analysis used data from the ongoing EURAS-LCS12 study, comparing outcomes across IUD types using descriptive statistics and incidence rates with 95% confidence intervals (CI).
RESULTS: Among 28,280 copper IUD users, copper-only IUDs were most common (63.4%) followed by copper-silver (32.4%) and copper-gold IUDs (4.2%). Overall, 114 PTC were reported within a follow-up time up to 113 months. The incidence of PTC was highest in copper-gold IUD users (copper-gold: 1.20 [95% CI, 0.86-1.70]; copper-silver: 0.21 [95% CI, 0.15-0.29]; copper-only: 0.09 [95% CI, 0.07-0.13] per 100 women-years [WY]). In total, we observed 28 events of PID with no substantial differences between groups (copper-only: 0.48 [95% CI, 0.29-0.75]; copper-silver: 0.40 [95% CI, 0.17-0.79]; copper-gold: 0.35 [95% CI, 0.01-2.00] per 1,000 WY). The incidence of unintended pregnancy was similar across groups (copper-gold: 0.46 [95% CI, 0.24-0.78]; copper-only: 0.43 [95% CI, 0.37-0.50]; copper-silver: 0.35 [95% CI, 0.27-0.45] per 100 WY).
CONCLUSION: We did not observe any differences in the clinical outcomes PID and unintended pregnancy between copper-only, copper-silver and copper-gold IUDs. However, copper-gold IUD users experienced more PTC.