Journal of cosmetic dermatology · 2025
Serum Vitamin D Levels and Its Relationship With Keloid, Acne or Hypertrophic Scar: A Two-Sample Mendelian Randomization Study.
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Ji Jiaqi, Shi Xinlong, Tang Enyu, Zheng Jiazhen, Liang Lei
Аннотация
BACKGROUND: Previous studies reported that patients with keloid, acne, or hypertrophic scar (HS) had lower serum vitamin D levels compared to healthy controls. Whereas, these works failed to verify their causal relationships. Hence, we performed a Mendelian randomization (MR) aimed to investigate the causal relationship between vitamin D and keloid, acne, or HS.
METHODS: Utilizing summary datasets from genome-wide association studies, we conducted a two-sample MR analysis to explore the causal relationship between vitamin D and keloid, acne, or HS. The inverse-variance weighted MR approach served as the primary analysis, with additional support from various sensitivity methods, including MR-Egger, weighted median, simple mode, weighted mode, and MR-PRESSO, to enhance the reliability of our findings.
RESULTS: From our MR analyses, no causal relationships were found between vitamin D level and keloid (OR: 1.15, 95% CI: 0.853-1.16, p = 0.36), acne (OR: 0.94, 95% CI: 0.66-1.30, p = 0.65) or HS (OR: 1.20, 95% CI 0.79-1.82, p = 0.40) formation. After eliminating outliers through MR-PRESSO, no significant associations were found between serum vitamin D level and keloid, acne, as well as HS.
CONCLUSION: Our findings, backed by rigorous IV selection and consistent outcomes across various MR approaches, suggest no causal link between serum 25(OH)D levels and keloid, acne, or HS. While vitamin D is involved in wound healing, its connection to these conditions may not be straightforward, emphasizing the need for further research.
METHODS: Utilizing summary datasets from genome-wide association studies, we conducted a two-sample MR analysis to explore the causal relationship between vitamin D and keloid, acne, or HS. The inverse-variance weighted MR approach served as the primary analysis, with additional support from various sensitivity methods, including MR-Egger, weighted median, simple mode, weighted mode, and MR-PRESSO, to enhance the reliability of our findings.
RESULTS: From our MR analyses, no causal relationships were found between vitamin D level and keloid (OR: 1.15, 95% CI: 0.853-1.16, p = 0.36), acne (OR: 0.94, 95% CI: 0.66-1.30, p = 0.65) or HS (OR: 1.20, 95% CI 0.79-1.82, p = 0.40) formation. After eliminating outliers through MR-PRESSO, no significant associations were found between serum vitamin D level and keloid, acne, as well as HS.
CONCLUSION: Our findings, backed by rigorous IV selection and consistent outcomes across various MR approaches, suggest no causal link between serum 25(OH)D levels and keloid, acne, or HS. While vitamin D is involved in wound healing, its connection to these conditions may not be straightforward, emphasizing the need for further research.