Effect of an integrated Yoga module on clinical, endocrine and metabolomic outcomes in polycystic ovarian syndrome.

Polycystic ovarian syndrome (PCOS) affects 5-20 % of women of reproductive age, with reproductive, metabolic, endocrine, and psychological consequences. Lifestyle interventions such as yoga provide safe, low-cost, and sustainable therapy. In this study, 25 women with PCOS underwent a 12-week yoga program (Asanas, Pranayama, Meditation) without concurrent therapy. Yoga improved menstrual regularity, normalized hormonal and metabolomic profiles. Biochemical analysis revealed reduced oxidative stress, enhanced mitochondrial function, improved insulin signaling, and decreased inflammation. Hormonal assays showed reduced luteinizing hormone (LH), anti-Müllerian hormone (AMH), dihydrotestosterone (DHT), and testosterone, with increased follicle-stimulating hormone (FSH), estradiol, and sex hormone-binding globulin (SHBG). Metabolomic improvements included reductions in glucose, fructose, d-ribose, xanthine, cholesterol, triglycerides, and body weight. These findings highlight yoga's potential to target core PCOS pathophysiology and support its use as a cost-effective, non-pharmacological, and sustainable therapy inn management of PCOS.