Translational vision science & technology · 2026
Impact of Swept-Source OCT Angiographic Scanning Speeds on the Detection of Choriocapillaris Flow Deficits in Eyes With AMD.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Beqiri Sara, Moxam Jillene, Pan Hefu, Kumar Bhagavath S, Berni Alessandro, Shen Mengxi, El-Mulki Omar S, Herrera Gissel, Badla Omar, Lam Winston, Herrera Eduardo, Ascioti Niccolò, Le Viet Hoan, Trivizki Omer, O'Brien Robert C, Waheed Nadia K, Wang Ruikang K, Gregori Giovanni, Rosenfeld Philip J
Аннотация
PURPOSE: The impact of swept-source optical coherence tomography angiography (SS-OCTA) scanning speeds (interscan times) on the quantification of choriocapillaris flow deficit percentages (CCFD%) was studied in eyes with nonexudative age-related macular degeneration.
METHODS: We conducted a retrospective review of 30 pairs of scans from 24 age-related macular degeneration subjects enrolled in an ongoing prospective SS-OCTA imaging study. Patients underwent imaging with same day scans at two scanning speeds: 100 kHz and 200 kHz (corresponding with 5.0-ms and 2.5-ms interscan times, respectively). Best practices for CC slab processing and CCFD quantification were implemented, and the compensation level was optimized for each scan. CCFD% measurements were obtained from the 3-mm and 5-mm fovea-centered circles.
RESULTS: The mean CCFD% measurements from the 3-mm fovea-centered circles for the 100-kHz and 200-kHz scans were 14.20% and 17.17% respectively, and 10.77% and 12.86% for the 5-mm circles. An agreement analysis showed a significant bias with mean values of 2.96% and 2.09% for the 3-mm and 5-mm circles. The limits of agreement extended predominantly in the positive direction with values of -1.96% to 7.89% and -0.60% to 4.78% in the 3-mm and 5-mm circles, respectively, that emphasize the systematically higher CCFD% recorded using the 200-kHz pattern. No confidence interval for the bias included zero, supporting the significant systematic bias across measurement strategies.
CONCLUSIONS: SS-OCTA scanning speeds have a significant impact on CCFD% quantification, with slower speeds yielding a lower CCFD%, likely due to the detection of slower CC flow, because of the higher associated interscan times.
TRANSLATIONAL RELEVANCE: When following and comparing choriocapillaris flow deficit percentage measurements over time, the same scanning speed should be used at each visit.
METHODS: We conducted a retrospective review of 30 pairs of scans from 24 age-related macular degeneration subjects enrolled in an ongoing prospective SS-OCTA imaging study. Patients underwent imaging with same day scans at two scanning speeds: 100 kHz and 200 kHz (corresponding with 5.0-ms and 2.5-ms interscan times, respectively). Best practices for CC slab processing and CCFD quantification were implemented, and the compensation level was optimized for each scan. CCFD% measurements were obtained from the 3-mm and 5-mm fovea-centered circles.
RESULTS: The mean CCFD% measurements from the 3-mm fovea-centered circles for the 100-kHz and 200-kHz scans were 14.20% and 17.17% respectively, and 10.77% and 12.86% for the 5-mm circles. An agreement analysis showed a significant bias with mean values of 2.96% and 2.09% for the 3-mm and 5-mm circles. The limits of agreement extended predominantly in the positive direction with values of -1.96% to 7.89% and -0.60% to 4.78% in the 3-mm and 5-mm circles, respectively, that emphasize the systematically higher CCFD% recorded using the 200-kHz pattern. No confidence interval for the bias included zero, supporting the significant systematic bias across measurement strategies.
CONCLUSIONS: SS-OCTA scanning speeds have a significant impact on CCFD% quantification, with slower speeds yielding a lower CCFD%, likely due to the detection of slower CC flow, because of the higher associated interscan times.
TRANSLATIONAL RELEVANCE: When following and comparing choriocapillaris flow deficit percentage measurements over time, the same scanning speed should be used at each visit.