Before considering immunoglobulins for Guillain-Barré syndrome as a cause of false-positive hepatitis serology, all other explanations should be ruled out!

A false-positive hepatitis serology result may not be solely due to intravenous immunoglobulins (IVIG) administration but may also result from cross-reacting antibodies from other infections, autoimmune diseases, recent hepatitis B vaccination, or interactions with rheumatoid factor or biotin. Furthermore, technical errors, such as faulty reagents or unsuitable testing methods, as well as certain patient groups, for example, those with certain chronic diseases, can also contribute to false-positive results. More likely than interference from IVIGs, the false-positive hepatitis serology result in one of the studies we read is due to Henoch-Schönlein pupura.