A Case of an Allergic Contact Dermatitis Following the Administration of Enoxaparin: A Case Report and Review of the Literature.

INTRODUCTION

Allergic contact dermatitis (ACD) is a rare but clinically significant hypersensitivity reaction to certain medications, including enoxaparin, a commonly used low-molecular-weight heparin (LMWH) for venous thromboembolism (VTE) prophylaxis.

CASE PRESENTATION: We report the case of a 27-year-old woman who developed pruritic, erythematous eruptions localized to enoxaparin injection sites following sleeve gastrectomy. Symptoms emerged 6 days after initiating enoxaparin and were confirmed as ACD via clinical assessment and histopathological analysis, which revealed spongiotic dermatitis with eosinophilic infiltration. The patient responded well to topical mometasone ointment, with complete resolution of symptoms within 4 weeks.

CONCLUSION

This case underscores the importance of recognizing enoxaparin-induced ACD and emphasizes the role of histopathology and individualized treatment strategies in optimizing patient care.