The Use of Vagus Nerve Stimulation (VNS) in the Management of Patients with Difficult-to-Treat Major Depressive Disorder (MDD): An Expert Consensus Statement.
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McAllister-Williams R Hamish, Alva Gustavo, Banov Michael, Conway Charles R, Cusin Cristina, De Beer Janetta C, Demyttenaere Koen, Domany Yoav, Domenech Philippe, Dougherty Darin D, Dunner David L, Feffer Kfir, George Mark S, Iosifescu Dan V, Kavakbasi Erhan, Kraus Christoph, Lehnhardt Fritz-Georg, Lesperance Paul, McCall William V, Murrough James W, Nahas Ziad, Nemeroff Charles B, Quevedo João, Reif-Leonhard Christine, Riva-Posse Patricio, Rush A John, Schwartz Thomas L, Stander Marthinus P, Williams Nolan R, Zajecka John, Aaronson Scott T, Baune Bernhard T, Sackeim Harold A
Аннотация
PATIENTS AND METHODS: A group of 32 experts in the use of VNS were identified from the main countries currently providing the treatment globally. A modified Delphi technique was used to document views on 55 statements regarding the goals, patient selection, and use of VNS treatment in routine clinical practice. Statements were rated on a 9-point Likert scale from "strongly disagree" to "strongly agree". Over the course of three rounds of voting, with statements modified based on anonymous comments from panelists, consensus agreement or disagreement was deemed if at least 75% of panel members scored a statement between 7 and 9, or 1 and 3, respectively.
RESULTS: Consensus was reached by the panel on 75% of the statements covering a wide range of issues. There was agreement that the main goals for VNS are long-term management of symptoms and improvement in quality of life, that the treatment is appropriate for all ages of patients and that there are few contraindications.
CONCLUSION: A set of expert recommendations for the use of VNS for DTD was generated. These should be of value to clinicians to ensure current best practices are followed when considering this treatment.