Journal of paediatrics and child health · 2005
Reye's syndrome developing in an infant on treatment of Kawasaki syndrome.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Wei Chih-Ming, Chen Huey-Ling, Lee Ping-Ing, Chen Chong-Ming, Ma Chun-Yi, Hwu Wuh-Liang
Аннотация
Aspirin is commonly used as an anti-inflammatory therapy for Kawasaki syndrome. Early initiation with high dose aspirin (80 to > 100 mg/kg per day), followed by low-dose therapy at the afebrile stage, has been often used to reduce morbidity and mortality in coronary complications. We report a 10-month-old infant who was diagnosed with Kawasaki syndrome. Sudden onset of poor activity, poor appetite, lethargy, tachycardia, tachypnea, hepatomegaly, increased AST/ALT, coagulopathy and hyperammonemia developed 3 days after the high-dose aspirin therapy. His histopathological and ultrastructural findings from the liver biopsy were compatible with Reye's syndrome. He recovered completely, and there was no recurrence.