Journal of neurovirology · 2022
Post-COVID-19 olfactory dysfunction: carbamazepine as a treatment option in a series of cases.
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Vasconcelos Claudia Cristina Ferreira, Hammerle Mariana Beiral, Sales Deborah Santos, Rueda Lopes Fernanda Cristina, Pinheiro Patricia Gomes, Gouvea Elisa Gutman, Alves Manuella Caroline Dutra Frazão, Pereira Tayane Vasconcellos, Schmidt Sergio Luis, Alvarenga Regina Maria Papais, Pires Karina Lebeis
Аннотация
Olfactory dysfunction is reported frequently in patients with coronavirus disease 2019. However, an effective treatment for this dysfunction is unknown. The present study evaluated carbamazepine as a treatment option for olfactory dysfunction based on its use in cases of neuralgia, especially of the V cranial nerve. The study included 10 patients with coronavirus disease with olfactory complaints who were part of a cohort of 172 coronavirus disease patients monitored for late neurological manifestations. Carbamazepine was administered for 11 weeks. The adverse effects reported were drowsiness (9/10) and dizziness (2/10); 9 of the 10 patients reported improved olfactory function after carbamazepine treatment. While the role of carbamazepine in the control of post-coronavirus disease olfactory dysfunction could not be confirmed in this study, the satisfactory response observed in most patients in this series suggests that further studies are warranted.