Journal of affective disorders reports · 2026
In the absence of Alzheimer's Disease pathology, PET-measured hippocampal tau is reduced in association with greater depressive symptoms: Could tau PET be sensitive to physiological tau involved in neurogenesis?
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hojjati Seyed Hani, Wang Xiuyuan Hugh, Zhou Liangdong, Keil Samantha, Tanzi Emily, Maloney Tom, Feiz Farnia, Shah Sudhin, Glodzik Lidia, Li Yi, Chiang Gloria C, Butler Tracy A
Аннотация
BACKGROUND: Tau Positron Emission Tomography (PET) visualizes hyperphosphorylated tau tangles which, together with Aβ plaques, are hallmark pathologies of Alzheimer's disease (AD). Greater tau, measured by PET or neuropathology, is robustly linked to worse cognition in AD, but associations with mood are less studied. We previously reported an unexpected inverse relationship between depressive symptoms and PET-measured medial temporal tau in individuals without AD. Here, we confirm and extend this finding in an independent cohort.
METHODS: We analyzed cross-sectional data from 403 Alzheimer's Disease Neuroimaging Initiative participants who underwent flortaucipir (tau) PET, Aβ PET, MRI, and clinical assessments including the Geriatric Depression Scale (GDS). Participants were categorized as Aβ- or Aβ+. Associations between GDS scores and mean hippocampal flortaucipir uptake were assessed using Spearman correlation and multiple regression.
RESULTS: In Aβ- individuals (n = 252), higher hippocampal tau was significantly associated with lower depression scores, whereas Aβ+ individuals (n = 151) showed a trend-level positive association. This difference was supported by a significant interaction between depression and Aβ status in regression analyses. Results were unchanged after adjustment for age, diagnostic group, and hippocampal volume.
CONCLUSIONS: In the absence of AD pathology, greater severity of depressive symptoms is associated with lower PET-measured hippocampal tau. Because impaired hippocampal neurogenesis is considered a key mechanism in depression, and tau is a normal component of cell division including neurogenesis, this replicated inverse relationship may reflect reduced hippocampal neurogenesis. Whether tau PET can provide a window into this process in humans requires further study.
METHODS: We analyzed cross-sectional data from 403 Alzheimer's Disease Neuroimaging Initiative participants who underwent flortaucipir (tau) PET, Aβ PET, MRI, and clinical assessments including the Geriatric Depression Scale (GDS). Participants were categorized as Aβ- or Aβ+. Associations between GDS scores and mean hippocampal flortaucipir uptake were assessed using Spearman correlation and multiple regression.
RESULTS: In Aβ- individuals (n = 252), higher hippocampal tau was significantly associated with lower depression scores, whereas Aβ+ individuals (n = 151) showed a trend-level positive association. This difference was supported by a significant interaction between depression and Aβ status in regression analyses. Results were unchanged after adjustment for age, diagnostic group, and hippocampal volume.
CONCLUSIONS: In the absence of AD pathology, greater severity of depressive symptoms is associated with lower PET-measured hippocampal tau. Because impaired hippocampal neurogenesis is considered a key mechanism in depression, and tau is a normal component of cell division including neurogenesis, this replicated inverse relationship may reflect reduced hippocampal neurogenesis. Whether tau PET can provide a window into this process in humans requires further study.