Physics and imaging in radiation oncology · 2026
Deep learning-enhanced image registration for accelerating daily adaptive magnetic resonance imaging-guided prostate radiotherapy.
СтатьяНазвание и аннотация: Перевод в очереди
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Zachiu Cornel, Bol Gijsbert H, Kotte Alexis N T J, Willigenburg Thomas, Maspero Matteo, Savenije Mark H F, de Boer Johannes C J, van der Voort van Zyp Jochem R N, van den Berg Cornelis A T, Raaymakers Bas W
Аннотация
BACKGROUND AND PURPOSE: Daily auto-contouring remains a workflow bottleneck in magnetic resonance-guided adaptive prostate radiotherapy (MRgRT). This study proposes and clinically validates a novel deep learning-enhanced deformable image registration (DIR) solution to accelerate this critical step.
MATERIALS AND METHODS: A hybrid framework combining a 3D nnU-Net segmenting bladder/rectum on planning/daily MRI with an in-house DIR algorithm was implemented for 5-fraction prostate MRgRT ( 5 × 7.25 Gy) on an MR-Linac. The DIR uses nnU-Net contours to propagate target and organs-of-interest structures. The solution was clinically deployed and evaluated in 275 patients/1375 fractions.
RESULTS: Evaluation following clinical introduction, has shown a median contouring time of ≈ 190 s, halving the time required by the previously-employed vendor-provided solution. Quantitative evaluation showed high agreement with clinically approved contours: Dice similarity coefficients > 0.9 and 95th percentile Hausdorff distances < 2.0 mm for most structures.
CONCLUSIONS: The implemented solution demonstrated reliable, high-accuracy daily auto-contouring, significantly accelerating MRgRT workflows. It has become our institutional standard for prostate treatments. Future work will extend this approach to additional treatment sites and modalities.
MATERIALS AND METHODS: A hybrid framework combining a 3D nnU-Net segmenting bladder/rectum on planning/daily MRI with an in-house DIR algorithm was implemented for 5-fraction prostate MRgRT ( 5 × 7.25 Gy) on an MR-Linac. The DIR uses nnU-Net contours to propagate target and organs-of-interest structures. The solution was clinically deployed and evaluated in 275 patients/1375 fractions.
RESULTS: Evaluation following clinical introduction, has shown a median contouring time of ≈ 190 s, halving the time required by the previously-employed vendor-provided solution. Quantitative evaluation showed high agreement with clinically approved contours: Dice similarity coefficients > 0.9 and 95th percentile Hausdorff distances < 2.0 mm for most structures.
CONCLUSIONS: The implemented solution demonstrated reliable, high-accuracy daily auto-contouring, significantly accelerating MRgRT workflows. It has become our institutional standard for prostate treatments. Future work will extend this approach to additional treatment sites and modalities.