Journal of the Endocrine Society · 2026
Clinical and genetic characteristics of head and neck paragangliomas from China featuring Sino-European comparisons.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Jun, Pang Yingxian, Yue Jianing, Shen Yanting, Zhang Jing, Li Minghao, Xu Xiaowen, Chen Bin, Yang Jue, Guo Daqiao, Wang Jing, Timmers Henri J L M, Pamporaki Christina, Kunst Henricus P M, Liu Longfei, Lu Zhiqiang, Zhang Zhiyin, Richter Susan, Jiang Jingjing
Аннотация
CONTEXT: Head and neck paragangliomas (HNPGLs) are tumors of parasympathetic origin, predominantly associated with pseudohypoxia and pathogenic variants (PVs) in succinate dehydrogenase (SDH) subunits, mainly based on studies in Europeans/Americans.
OBJECTIVE: This work aimed to assess the genetics of HNPGLs in a large Chinese cohort and compare them with European cases.
METHODS: A retrospective cohort study was conducted of HNPGLs from 2 Chinese tertiary-care centers and 2 European centers. Participants included 222 Chinese and 205 European HNPGL patients. Main outcome measures included clinical presentation and genetic status assessed via next-generation sequencing of tumor/blood samples.
RESULTS: The Chinese HNPGL cohort consisted mainly of carotid body HNPGLs (86.9%), fewer jugulotympanic (12.2%), and no vagal HNPGLs. Jugulotympanic HNPGLs showed higher recurrence than carotid body HNPGLs (30.4% vs 8.5%; P = .009). PVs were detected in 62.2% of Chinese patients, predominantly in SDHx genes. PV frequency was higher in carotid body than jugulotympanic HNPGLs (65.8% vs 37%; P = .004), and in more male than female patients (75.9% vs 54.0%; P = .001). Compared to those without SDHx PVs, SDHx PVs carriers were younger (41.0 vs 49.0; P < .001), with more multifocal tumors (20.8% vs 7.6%; P = .007) and less often female (53.1% vs 76.1%; P < .001). Compared with Europeans, Chinese patients were younger (45.0 vs 54.3; P < .001), with fewer multilocal HNPGLs (0.9 vs 13.7%; P < .001), lower rates of recurrence (13.7% vs 28.0%; P = .007), but similar metastasis rates (3.9% vs 5.0%; P = .668).
CONCLUSION: This is the first report of HNPGLs in a large Chinese cohort. Clinical presentation and practice as well as ancestry all likely contribute to the differences observed between Chinese and European patients.
OBJECTIVE: This work aimed to assess the genetics of HNPGLs in a large Chinese cohort and compare them with European cases.
METHODS: A retrospective cohort study was conducted of HNPGLs from 2 Chinese tertiary-care centers and 2 European centers. Participants included 222 Chinese and 205 European HNPGL patients. Main outcome measures included clinical presentation and genetic status assessed via next-generation sequencing of tumor/blood samples.
RESULTS: The Chinese HNPGL cohort consisted mainly of carotid body HNPGLs (86.9%), fewer jugulotympanic (12.2%), and no vagal HNPGLs. Jugulotympanic HNPGLs showed higher recurrence than carotid body HNPGLs (30.4% vs 8.5%; P = .009). PVs were detected in 62.2% of Chinese patients, predominantly in SDHx genes. PV frequency was higher in carotid body than jugulotympanic HNPGLs (65.8% vs 37%; P = .004), and in more male than female patients (75.9% vs 54.0%; P = .001). Compared to those without SDHx PVs, SDHx PVs carriers were younger (41.0 vs 49.0; P < .001), with more multifocal tumors (20.8% vs 7.6%; P = .007) and less often female (53.1% vs 76.1%; P < .001). Compared with Europeans, Chinese patients were younger (45.0 vs 54.3; P < .001), with fewer multilocal HNPGLs (0.9 vs 13.7%; P < .001), lower rates of recurrence (13.7% vs 28.0%; P = .007), but similar metastasis rates (3.9% vs 5.0%; P = .668).
CONCLUSION: This is the first report of HNPGLs in a large Chinese cohort. Clinical presentation and practice as well as ancestry all likely contribute to the differences observed between Chinese and European patients.